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NCT06538038Active, not recruiting

Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

Prospective Non-Interventional Study Comparing Standard of Care Osimertinib +/- Chemotherapy for EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC) Patients

Source: ClinicalTrials.gov · Last updated 9 Sept 2026

Brief summary (registry, in English)

The goal of the study is to collect data on patients treated outside of a clinical trial (in routine clinical practice) with standard of care osimertinib with or without chemotherapy in Epidermal Growth Factor Receptor (EGFR)-mutant Non-Small Cell Lung Cancer (NSCLC) to better understand the safety and effectiveness of these standard of care regimens.

Status (registry)
Active, not recruiting
Study type
Observational
Enrollment
200 (actual)
First submitted
31 Jul 2024
Start date
17 Sept 2024
Primary completion date
Aug 2028
Lead sponsor
PrECOG, LLC.
Diseases
Lung cancer
NCT number
NCT06538038

What you commit to

  • Study type: Observational
  • Participants enrolled: 200
  • From 17 Sept 2024 to the primary completion date, Aug 2028
  • 145 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

  • Patient must have a pathologically-confirmed diagnosis of non-small cell lung cancer (NSCLC).
  • Patient must have advanced disease, defined as IIIB (not amenable to definitive multi-modality therapy), IIIC, or IV (includes local or distant recurrent disease after a prior diagnosis of Stage I-III disease). All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria.
  • Patient tumor must have somatic activating sensitizing mutation in EGFR (e.g., but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Plasma, cytology, or tumor tissue can be utilized for standard of care mutation testing.
  • Prior chemotherapy and/or immunotherapy administered as primary treatment for NSCLC before EGFR mutation was identified is allowed ≤ 45 days of study registration to allow for return of sequencing information.
  • Prior treatment with osimertinib administered as primary treatment for NSCLC is allowed ≤ 30 days of study registration (prior treatment with any other EGFR TKI agent is not allowed).
  • Patient must not be participating in EA5182 or any other cancer treatment trial. Osimertinib or osimertinib + chemotherapy/immunotherapy given as first-line treatment for this disease cannot be given as part of a clinical trial.
  • Patients that have received prior radiation therapy in any setting for this disease are eligible.
  • Adults age ≥ 18 years.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (145)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
ThedaCare Regional Medical Center - Appleton
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AppletonUnited StatesUnknown status
ThedaCare Regional Cancer Center
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AppletonUnited StatesUnknown status
University of Maryland Greenebaum Comprehensive Cancer Center
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BaltimoreUnited StatesUnknown status
Greater Baltimore Medical Center
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BaltimoreUnited StatesUnknown status
Advocate Good Shepherd Hospital
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BarringtonUnited StatesUnknown status
ThedaCare Cancer Care - Berlin
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BerlinUnited StatesUnknown status
University of Alabama at Birmingham
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BirminghamUnited StatesUnknown status
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: SJC Bluffton Campus
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BlufftonUnited StatesUnknown status
Tufts Medical Center
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BostonUnited StatesUnknown status
Aurora Cancer Care-Southern Lakes VLCC
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BurlingtonUnited StatesUnknown status
Minnesota Oncology - Burnsville
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BurnsvilleUnited StatesUnknown status
Cambridge Medical Center
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CambridgeUnited StatesUnknown status
Aultman
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CantonUnited StatesUnknown status
Miami Valley Hospital South
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CentervilleUnited StatesUnknown status
Northwestern University
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ChicagoUnited StatesUnknown status
John H Stroger Jr Hospital of Cook County
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ChicagoUnited StatesUnknown status
Advocate Illinois Masonic Medical Center
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ChicagoUnited StatesUnknown status
Baptist Memorial Hospital and Cancer Center-Collierville
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ColliervilleUnited StatesUnknown status
Baptist Memorial Hospital and Cancer Center-Golden Triangle
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ColumbusUnited StatesUnknown status
Mercy Hospital
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Coon RapidsUnited StatesUnknown status
Aurora Saint Luke's South Shore
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CudahyUnited StatesUnknown status
UT Southwest
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DallasUnited StatesUnknown status
Geisinger Medical Center
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DanvilleUnited StatesUnknown status
Northwestern Medicine Cancer Center Kishwaukee
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DeKalbUnited StatesUnknown status
Bayhealth
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DoverUnited StatesUnknown status
The Cancer Institute at St. Francis Hospital
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East HillsUnited StatesUnknown status
Fairview Southdale Hospital
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EdinaUnited StatesUnknown status
Stanford Cancer Center Emeryville
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EmeryvilleUnited StatesUnknown status
Miami Valley Hospital North
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EnglewoodUnited StatesUnknown status
Mercy Research
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Fort SmithUnited StatesUnknown status
Mercy Clinic Fort Smith Communities
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Fort SmithUnited StatesUnknown status
JPS Oncology & Infusion Center
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Fort WorthUnited StatesUnknown status
Atrium Medical Center-Middletown Regional Hospital
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FranklinUnited StatesUnknown status
Northwestern Medicine Cancer Center Delnor
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GenevaUnited StatesUnknown status
AHC Germantown Health Center
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GermantownUnited StatesUnknown status
Northwestern Medicine Glenview Outpatient Center
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GlenviewUnited StatesUnknown status
Aurora Cancer Care-Grafton
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GraftonUnited StatesUnknown status
Northwestern Medicine Grayslake Outpatient Center
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GrayslakeUnited StatesUnknown status
Aurora BayCare Medical Center
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Green BayUnited StatesUnknown status
Miami Valley Cancer Care and Infusion
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GreenvilleUnited StatesUnknown status
Baptist Cancer Center-Grenada
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GrenadaUnited StatesUnknown status
Advocate South Suburban Hospital
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Hazel CrestUnited StatesUnknown status
Geisinger Medical Center-Cancer Center Hazleton
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HazletonUnited StatesUnknown status
UNC Pardee Cancer Center
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HendersonvilleUnited StatesUnknown status
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: South Carolina Cancer Specialists
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Hilton Head IslandUnited StatesUnknown status
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Liberty County Cancer Care
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HinesvilleUnited StatesUnknown status
Jackson Oncology Associates PLLC
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JacksonUnited StatesUnknown status
Mississippi Baptist Medical Center
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JacksonUnited StatesUnknown status
Mercyhealth Hospital and Cancer Center - Janesville
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JanesvilleUnited StatesUnknown status
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Regional Cancer Care
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JesupUnited StatesUnknown status
Fowler Family Cancer Center - Jonesboro
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JonesboroUnited StatesUnknown status
Mercy Clinic Joplin, LLC
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JoplinUnited StatesUnknown status
Aurora Cancer Care-Kenosha South
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KenoshaUnited StatesUnknown status
Gundersen Lutheran Medical Foundation
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La CrosseUnited StatesUnknown status
Northwestern Medicine Lake Forest Hospital
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Lake ForestUnited StatesUnknown status
Geisinger Medical Oncology-Lewisburg
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LewisburgUnited StatesUnknown status
Lewistown Hospital
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LewistownUnited StatesUnknown status
Lowell General Hosptial
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LowellUnited StatesUnknown status
University of Wisconsin Carbone Cancer Center
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MadisonUnited StatesUnknown status
Fairview Clinics and Surgery Center Maple Grove
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Maple GroveUnited StatesUnknown status
Minnesota Oncology Hematology PA-Maplewood
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MaplewoodUnited StatesUnknown status
Saint John's Hospital - Healtheast
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MaplewoodUnited StatesUnknown status
Marshfield Medical Center
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MarshfieldUnited StatesUnknown status
Baptist Memorial Hospital and Cancer Center-Memphis
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MemphisUnited StatesUnknown status
Baptist Memorial Hospital for Women
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MemphisUnited StatesUnknown status
Satellite of Bayhealth Sussex
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MilfordUnited StatesUnknown status
Aurora NCORP
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MilwaukeeUnited StatesUnknown status
Aurora Sinai Medical Center
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MilwaukeeUnited StatesUnknown status
Aurora West Allis Medical Center
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MilwaukeeUnited StatesUnknown status
Aurora Cancer Care-Milwaukee
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MilwaukeeUnited StatesUnknown status
Aurora Saint Luke's Medical Center
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MilwaukeeUnited StatesUnknown status
Abbott-Northwestern Hospital
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MinneapolisUnited StatesUnknown status
Health Partners Inc
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MinneapolisUnited StatesUnknown status
Hennepin County Medical Center
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MinneapolisUnited StatesUnknown status
Monticello Cancer Center
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MonticelloUnited StatesUnknown status
Virtua Samson Cancer Center
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MoorestownUnited StatesUnknown status
Atlantic Health Cancer Consortium Community Oncology Research Program
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MorristownUnited StatesUnknown status
Morristown Medical Center
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MorristownUnited StatesUnknown status
Vanderbilt University
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NashvilleUnited StatesUnknown status
ThedaCare Regional Medical Center - Neenah
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NeenahUnited StatesUnknown status
Baptist Memorial Hospital and Cancer Center - Union
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New AlbanyUnited StatesUnknown status
Rutgers Cancer Institute of New Jersey
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New BrunswickUnited StatesUnknown status
ThedaCare Cancer Care - New London
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New LondonUnited StatesUnknown status
New Ulm Medical Center
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New UlmUnited StatesUnknown status
Montefiore
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New YorkUnited StatesUnknown status
Carle Cancer Institute Normal
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NormalUnited StatesUnknown status
Advocate Christ Medical Center
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Oak LawnUnited StatesUnknown status
Mercy Clinic Oklahoma Communities, Inc.
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Oklahoma CityUnited StatesUnknown status
Northwestern Medicine Orland Park
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Orland ParkUnited StatesUnknown status
Vince Lombardi Cancer Clinic - Oshkosh
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OshkoshUnited StatesUnknown status
ThedaCare Cancer Care - Oshkosh
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OshkoshUnited StatesUnknown status
Baptist Memorial Hospital and Cancer Center-Oxford
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OxfordUnited StatesUnknown status
Stanford Cancer Institute Palo Alto
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Palo AltoUnited StatesUnknown status
Lankenau Medical Center
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PaoliUnited StatesUnknown status
The Valley Hospital - Luckow Pavilion
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ParamusUnited StatesUnknown status
Advocate Lutheran General Hospital
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Park RidgeUnited StatesUnknown status
University of Pennsylvania
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PhiladelphiaUnited StatesUnknown status
Thomas Jefferson University Hospital
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PhiladelphiaUnited StatesUnknown status
Jefferson Torresdale Hospital
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PhiladelphiaUnited StatesUnknown status
Einstein Medical Center
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PhiladelphiaUnited StatesUnknown status
FirstHealth of the Carolinas-Moore Regional Hospital
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PinehurstUnited StatesUnknown status
Allegheny General Hospital
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PittsburghUnited StatesUnknown status
Geisinger Cancer Services-Pottsville
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PottsvilleUnited StatesUnknown status
Fairview Northland Medical Center
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PrincetonUnited StatesUnknown status
Aurora Cancer Care-Racine
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RacineUnited StatesUnknown status
North Memorial Medical Health Center
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RobbinsdaleUnited StatesUnknown status
Mercy Clinic Cancer and Hematology
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RollaUnited StatesUnknown status
Park Nicollet Clinic - Saint Louis Park
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Saint Louis ParkUnited StatesUnknown status
Metro MN
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Saint Louis ParkUnited StatesUnknown status
Regions Hospital
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Saint PaulUnited StatesUnknown status
United Hospital
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Saint PaulUnited StatesUnknown status
Stanford Cancer Center South Bay
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San JoseUnited StatesUnknown status
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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SavannahUnited StatesUnknown status
Community Medical Center
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ScrantonUnited StatesUnknown status
Sidney Kimmel Cancer Center Washington Township
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SewellUnited StatesUnknown status
Saint Francis Regional Medical Center
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ShakopeeUnited StatesUnknown status
ThedaCare Cancer Care - Shawano
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ShawanoUnited StatesUnknown status
Vince Lombardi Cancer Clinic-Sheboygan
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SheboyganUnited StatesUnknown status
Baptist Memorial Hospital and Cancer Center-Desoto
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SouthhavenUnited StatesUnknown status
Mercy Clinic Springfield Communities
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SpringfieldUnited StatesUnknown status
Geisinger Medical Group
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State CollegeUnited StatesUnknown status
Lakeview Hospital
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StillwaterUnited StatesUnknown status
Mercy Clinic East Communities
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St LouisUnited StatesUnknown status
Tufts Medical Center Cancer Center Stoneham
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StonehamUnited StatesUnknown status
Aurora Medical Center in Summit
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SummitUnited StatesUnknown status
Overlook Medical Center
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SummitUnited StatesUnknown status
SUNY Upstate Medical University
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SyracuseUnited StatesUnknown status
Montefiore Medical Center-Einstein Campus
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The BronxUnited StatesUnknown status
Upper Valley Medical Center
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TroyUnited StatesUnknown status
Vince Lombardi Cancer Clinic-Two Rivers
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Two RiversUnited StatesUnknown status
Carle Founation Hospital
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UrbanaUnited StatesUnknown status
Virtua Voorhees
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Voorhees TownshipUnited StatesUnknown status
Ridgeview Medical Center
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WaconiaUnited StatesUnknown status
John Muir Health
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Walnut CreekUnited StatesUnknown status
Northwestern Medicine Cancer Center Warrenville
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WarrenvilleUnited StatesUnknown status
Sibley Johns Hopkins University
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Washington D.C.United StatesUnknown status
ProHealth
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WaukeshaUnited StatesUnknown status
ThedaCare Cancer Care - Waupaca
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WaupacaUnited StatesUnknown status
Aurora Cancer Care-Milwaukee West
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WauwatosaUnited StatesUnknown status
Good Samaritan University Hospital
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West IslipUnited StatesUnknown status
Geisinger Wyoming Valley/Henry Cancer Center
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Wilkes-BarreUnited StatesUnknown status
Rice Memorial Hospital
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WillmarUnited StatesUnknown status
Asplundh Cancer Pavilion
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Willow GroveUnited StatesUnknown status
Minnesota Oncology Hematology PA-Woodbury
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WoodburyUnited StatesUnknown status
Fairview Lakes Medical Center
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WyomingUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.