NCT06538038Active, not recruiting
Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
Prospective Non-Interventional Study Comparing Standard of Care Osimertinib +/- Chemotherapy for EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC) Patients
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
The goal of the study is to collect data on patients treated outside of a clinical trial (in routine clinical practice) with standard of care osimertinib with or without chemotherapy in Epidermal Growth Factor Receptor (EGFR)-mutant Non-Small Cell Lung Cancer (NSCLC) to better understand the safety and effectiveness of these standard of care regimens.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 200 (actual)
- First submitted
- 31 Jul 2024
- Start date
- 17 Sept 2024
- Primary completion date
- Aug 2028
- Lead sponsor
- PrECOG, LLC.
- Diseases
- Lung cancer
- NCT number
- NCT06538038
What you commit to
- Study type: Observational
- Participants enrolled: 200
- From 17 Sept 2024 to the primary completion date, Aug 2028
- 145 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Patient must have a pathologically-confirmed diagnosis of non-small cell lung cancer (NSCLC).
- Patient must have advanced disease, defined as IIIB (not amenable to definitive multi-modality therapy), IIIC, or IV (includes local or distant recurrent disease after a prior diagnosis of Stage I-III disease). All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria.
- Patient tumor must have somatic activating sensitizing mutation in EGFR (e.g., but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Plasma, cytology, or tumor tissue can be utilized for standard of care mutation testing.
- Prior chemotherapy and/or immunotherapy administered as primary treatment for NSCLC before EGFR mutation was identified is allowed ≤ 45 days of study registration to allow for return of sequencing information.
- Prior treatment with osimertinib administered as primary treatment for NSCLC is allowed ≤ 30 days of study registration (prior treatment with any other EGFR TKI agent is not allowed).
- Patient must not be participating in EA5182 or any other cancer treatment trial. Osimertinib or osimertinib + chemotherapy/immunotherapy given as first-line treatment for this disease cannot be given as part of a clinical trial.
- Patients that have received prior radiation therapy in any setting for this disease are eligible.
- Adults age ≥ 18 years.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (145)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ThedaCare Regional Medical Center - Appleton Coordinator of this site? Confirm its status | Appleton | United States | Unknown status |
| ThedaCare Regional Cancer Center Coordinator of this site? Confirm its status | Appleton | United States | Unknown status |
| University of Maryland Greenebaum Comprehensive Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Greater Baltimore Medical Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Advocate Good Shepherd Hospital Coordinator of this site? Confirm its status | Barrington | United States | Unknown status |
| ThedaCare Cancer Care - Berlin Coordinator of this site? Confirm its status | Berlin | United States | Unknown status |
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: SJC Bluffton Campus Coordinator of this site? Confirm its status | Bluffton | United States | Unknown status |
| Tufts Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Aurora Cancer Care-Southern Lakes VLCC Coordinator of this site? Confirm its status | Burlington | United States | Unknown status |
| Minnesota Oncology - Burnsville Coordinator of this site? Confirm its status | Burnsville | United States | Unknown status |
| Cambridge Medical Center Coordinator of this site? Confirm its status | Cambridge | United States | Unknown status |
| Aultman Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Miami Valley Hospital South Coordinator of this site? Confirm its status | Centerville | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| John H Stroger Jr Hospital of Cook County Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Advocate Illinois Masonic Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Collierville Coordinator of this site? Confirm its status | Collierville | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| Aurora Saint Luke's South Shore Coordinator of this site? Confirm its status | Cudahy | United States | Unknown status |
| UT Southwest Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Geisinger Medical Center Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Northwestern Medicine Cancer Center Kishwaukee Coordinator of this site? Confirm its status | DeKalb | United States | Unknown status |
| Bayhealth Coordinator of this site? Confirm its status | Dover | United States | Unknown status |
| The Cancer Institute at St. Francis Hospital Coordinator of this site? Confirm its status | East Hills | United States | Unknown status |
| Fairview Southdale Hospital Coordinator of this site? Confirm its status | Edina | United States | Unknown status |
| Stanford Cancer Center Emeryville Coordinator of this site? Confirm its status | Emeryville | United States | Unknown status |
| Miami Valley Hospital North Coordinator of this site? Confirm its status | Englewood | United States | Unknown status |
| Mercy Research Coordinator of this site? Confirm its status | Fort Smith | United States | Unknown status |
| Mercy Clinic Fort Smith Communities Coordinator of this site? Confirm its status | Fort Smith | United States | Unknown status |
| JPS Oncology & Infusion Center Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Atrium Medical Center-Middletown Regional Hospital Coordinator of this site? Confirm its status | Franklin | United States | Unknown status |
| Northwestern Medicine Cancer Center Delnor Coordinator of this site? Confirm its status | Geneva | United States | Unknown status |
| AHC Germantown Health Center Coordinator of this site? Confirm its status | Germantown | United States | Unknown status |
| Northwestern Medicine Glenview Outpatient Center Coordinator of this site? Confirm its status | Glenview | United States | Unknown status |
| Aurora Cancer Care-Grafton Coordinator of this site? Confirm its status | Grafton | United States | Unknown status |
| Northwestern Medicine Grayslake Outpatient Center Coordinator of this site? Confirm its status | Grayslake | United States | Unknown status |
| Aurora BayCare Medical Center Coordinator of this site? Confirm its status | Green Bay | United States | Unknown status |
| Miami Valley Cancer Care and Infusion Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Baptist Cancer Center-Grenada Coordinator of this site? Confirm its status | Grenada | United States | Unknown status |
| Advocate South Suburban Hospital Coordinator of this site? Confirm its status | Hazel Crest | United States | Unknown status |
| Geisinger Medical Center-Cancer Center Hazleton Coordinator of this site? Confirm its status | Hazleton | United States | Unknown status |
| UNC Pardee Cancer Center Coordinator of this site? Confirm its status | Hendersonville | United States | Unknown status |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: South Carolina Cancer Specialists Coordinator of this site? Confirm its status | Hilton Head Island | United States | Unknown status |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Liberty County Cancer Care Coordinator of this site? Confirm its status | Hinesville | United States | Unknown status |
| Jackson Oncology Associates PLLC Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Mississippi Baptist Medical Center Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Mercyhealth Hospital and Cancer Center - Janesville Coordinator of this site? Confirm its status | Janesville | United States | Unknown status |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Regional Cancer Care Coordinator of this site? Confirm its status | Jesup | United States | Unknown status |
| Fowler Family Cancer Center - Jonesboro Coordinator of this site? Confirm its status | Jonesboro | United States | Unknown status |
| Mercy Clinic Joplin, LLC Coordinator of this site? Confirm its status | Joplin | United States | Unknown status |
| Aurora Cancer Care-Kenosha South Coordinator of this site? Confirm its status | Kenosha | United States | Unknown status |
| Gundersen Lutheran Medical Foundation Coordinator of this site? Confirm its status | La Crosse | United States | Unknown status |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Unknown status |
| Geisinger Medical Oncology-Lewisburg Coordinator of this site? Confirm its status | Lewisburg | United States | Unknown status |
| Lewistown Hospital Coordinator of this site? Confirm its status | Lewistown | United States | Unknown status |
| Lowell General Hosptial Coordinator of this site? Confirm its status | Lowell | United States | Unknown status |
| University of Wisconsin Carbone Cancer Center Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| Fairview Clinics and Surgery Center Maple Grove Coordinator of this site? Confirm its status | Maple Grove | United States | Unknown status |
| Minnesota Oncology Hematology PA-Maplewood Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| Saint John's Hospital - Healtheast Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| Marshfield Medical Center Coordinator of this site? Confirm its status | Marshfield | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Memphis Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Baptist Memorial Hospital for Women Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Satellite of Bayhealth Sussex Coordinator of this site? Confirm its status | Milford | United States | Unknown status |
| Aurora NCORP Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Aurora Sinai Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Aurora West Allis Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Aurora Cancer Care-Milwaukee Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Aurora Saint Luke's Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Health Partners Inc Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Hennepin County Medical Center Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Monticello Cancer Center Coordinator of this site? Confirm its status | Monticello | United States | Unknown status |
| Virtua Samson Cancer Center Coordinator of this site? Confirm its status | Moorestown | United States | Unknown status |
| Atlantic Health Cancer Consortium Community Oncology Research Program Coordinator of this site? Confirm its status | Morristown | United States | Unknown status |
| Morristown Medical Center Coordinator of this site? Confirm its status | Morristown | United States | Unknown status |
| Vanderbilt University Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| ThedaCare Regional Medical Center - Neenah Coordinator of this site? Confirm its status | Neenah | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center - Union Coordinator of this site? Confirm its status | New Albany | United States | Unknown status |
| Rutgers Cancer Institute of New Jersey Coordinator of this site? Confirm its status | New Brunswick | United States | Unknown status |
| ThedaCare Cancer Care - New London Coordinator of this site? Confirm its status | New London | United States | Unknown status |
| New Ulm Medical Center Coordinator of this site? Confirm its status | New Ulm | United States | Unknown status |
| Montefiore Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Carle Cancer Institute Normal Coordinator of this site? Confirm its status | Normal | United States | Unknown status |
| Advocate Christ Medical Center Coordinator of this site? Confirm its status | Oak Lawn | United States | Unknown status |
| Mercy Clinic Oklahoma Communities, Inc. Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Northwestern Medicine Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Unknown status |
| Vince Lombardi Cancer Clinic - Oshkosh Coordinator of this site? Confirm its status | Oshkosh | United States | Unknown status |
| ThedaCare Cancer Care - Oshkosh Coordinator of this site? Confirm its status | Oshkosh | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Oxford Coordinator of this site? Confirm its status | Oxford | United States | Unknown status |
| Stanford Cancer Institute Palo Alto Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| Lankenau Medical Center Coordinator of this site? Confirm its status | Paoli | United States | Unknown status |
| The Valley Hospital - Luckow Pavilion Coordinator of this site? Confirm its status | Paramus | United States | Unknown status |
| Advocate Lutheran General Hospital Coordinator of this site? Confirm its status | Park Ridge | United States | Unknown status |
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Thomas Jefferson University Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Jefferson Torresdale Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Einstein Medical Center Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| FirstHealth of the Carolinas-Moore Regional Hospital Coordinator of this site? Confirm its status | Pinehurst | United States | Unknown status |
| Allegheny General Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Geisinger Cancer Services-Pottsville Coordinator of this site? Confirm its status | Pottsville | United States | Unknown status |
| Fairview Northland Medical Center Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Aurora Cancer Care-Racine Coordinator of this site? Confirm its status | Racine | United States | Unknown status |
| North Memorial Medical Health Center Coordinator of this site? Confirm its status | Robbinsdale | United States | Unknown status |
| Mercy Clinic Cancer and Hematology Coordinator of this site? Confirm its status | Rolla | United States | Unknown status |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Metro MN Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| United Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Stanford Cancer Center South Bay Coordinator of this site? Confirm its status | San Jose | United States | Unknown status |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Coordinator of this site? Confirm its status | Savannah | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Scranton | United States | Unknown status |
| Sidney Kimmel Cancer Center Washington Township Coordinator of this site? Confirm its status | Sewell | United States | Unknown status |
| Saint Francis Regional Medical Center Coordinator of this site? Confirm its status | Shakopee | United States | Unknown status |
| ThedaCare Cancer Care - Shawano Coordinator of this site? Confirm its status | Shawano | United States | Unknown status |
| Vince Lombardi Cancer Clinic-Sheboygan Coordinator of this site? Confirm its status | Sheboygan | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Desoto Coordinator of this site? Confirm its status | Southhaven | United States | Unknown status |
| Mercy Clinic Springfield Communities Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Geisinger Medical Group Coordinator of this site? Confirm its status | State College | United States | Unknown status |
| Lakeview Hospital Coordinator of this site? Confirm its status | Stillwater | United States | Unknown status |
| Mercy Clinic East Communities Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Tufts Medical Center Cancer Center Stoneham Coordinator of this site? Confirm its status | Stoneham | United States | Unknown status |
| Aurora Medical Center in Summit Coordinator of this site? Confirm its status | Summit | United States | Unknown status |
| Overlook Medical Center Coordinator of this site? Confirm its status | Summit | United States | Unknown status |
| SUNY Upstate Medical University Coordinator of this site? Confirm its status | Syracuse | United States | Unknown status |
| Montefiore Medical Center-Einstein Campus Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Upper Valley Medical Center Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Vince Lombardi Cancer Clinic-Two Rivers Coordinator of this site? Confirm its status | Two Rivers | United States | Unknown status |
| Carle Founation Hospital Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Virtua Voorhees Coordinator of this site? Confirm its status | Voorhees Township | United States | Unknown status |
| Ridgeview Medical Center Coordinator of this site? Confirm its status | Waconia | United States | Unknown status |
| John Muir Health Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Northwestern Medicine Cancer Center Warrenville Coordinator of this site? Confirm its status | Warrenville | United States | Unknown status |
| Sibley Johns Hopkins University Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| ProHealth Coordinator of this site? Confirm its status | Waukesha | United States | Unknown status |
| ThedaCare Cancer Care - Waupaca Coordinator of this site? Confirm its status | Waupaca | United States | Unknown status |
| Aurora Cancer Care-Milwaukee West Coordinator of this site? Confirm its status | Wauwatosa | United States | Unknown status |
| Good Samaritan University Hospital Coordinator of this site? Confirm its status | West Islip | United States | Unknown status |
| Geisinger Wyoming Valley/Henry Cancer Center Coordinator of this site? Confirm its status | Wilkes-Barre | United States | Unknown status |
| Rice Memorial Hospital Coordinator of this site? Confirm its status | Willmar | United States | Unknown status |
| Asplundh Cancer Pavilion Coordinator of this site? Confirm its status | Willow Grove | United States | Unknown status |
| Minnesota Oncology Hematology PA-Woodbury Coordinator of this site? Confirm its status | Woodbury | United States | Unknown status |
| Fairview Lakes Medical Center Coordinator of this site? Confirm its status | Wyoming | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.