NCT06538259Completed
Effects of tDCS Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia
Effects of Transcranial Direct Current Stimulation Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia
Source: ClinicalTrials.gov · Last updated 5 Aug 2024
Brief summary (registry, in English)
The semantic processing deficit stands as a central feature of cognitive abnormalities in schizophrenia. Both transcranial direct current stimulation (tDCS) and retrieval practice have been demonstrated as external techniques capable of ameliorating the semantic processing deficit in individuals with schizophrenia. The inquiry examines whether the combined effect of tDCS and retrieval practice, following tDCS intervention targeting the left dorsolateral prefrontal cortex (L-DLPFC) in patients with schizophrenia, contributes to the preservation of semantic memory in these individuals. Investigators recruited 52 patients diagnosed with schizophrenia from hospitals. After five consecutive days of tDCS intervention (2 mA × 20 mins, twice per day), Investigators administered a word list memorization task comparing retrieval practice and restudy strategies. Subsequently, Investigators observed their immediate and delayed memory performance through tests.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 52 (actual)
- First submitted
- 27 Jul 2024
- Start date
- 24 Jul 2023
- Primary completion date
- 30 Jan 2024
- Lead sponsor
- Northeast Normal University
- Diseases
- Schizophrenia
- NCT number
- NCT06538259
What you commit to
- Study type: Interventional
- Participants enrolled: 52
- From 24 Jul 2023 to the primary completion date, 30 Jan 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in similar experiments in the past 30 days prior to baseline.
Other illness
- Clear cognitive impairment caused by somatic or cerebral organic lesions, such as cerebrovascular diseases, traumatic brain injury, etc;
- Individuals with mental disorders caused by substance dependence or abuse, or the use of psychoactive substances;
- History of brain injury or other central nervous system-related organic diseases;
Other
- Individuals at significant risk of suicide or harming others;
Who the study is looking for
- Meeting the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);
- Aged 18 years or older, regardless of gender, with an educational level of elementary school or above;
- All patients received stable-level antipsychotic medication treatment, were in a stable phase of disease treatment, able to understand the testing requirements, and cooperated to complete all research tasks;
- No history of neurological disorders or other serious physical illnesses, and no history of intellectual disability;
- No color blindness, color weakness, or other color vision impairments, with normal vision or corrected vision.
Age in the registry: 19 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Northwest Normal University Coordinator of this site? Confirm its status | Lanzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.