NCT06538636Recruiting
Prediction Augmented Screening Initiative
Source: ClinicalTrials.gov · Last updated 26 Jun 2026
Brief summary (registry, in English)
Lung cancer is responsible for more deaths in the United States than breast, prostate and colon cancer combined and is the number one cancer killer of Veterans. This is because lung cancer is usually diagnosed when the disease has spread, and cure is less likely. Lung cancer screening (LCS) finds cancer at an earlier stage when it is curable, yet only 20% of eligible Veterans have been screened. Uptake is even lower among Black Veterans despite higher lung cancer risk. Using prediction models to identify high-benefit people for whom LCS should be encouraged improves efficiency and reduces disparities. Moreover, it is more patient-centered as shared decision-making conversations can be tailored with personalized information. The US Preventive Services Task Force has called for research to demonstrate that prediction-augmented LCS can be feasibly implemented at the point-of-care. The investigators propose for VA to lead this effort with a large-scale pragmatic clinical trial to show that prediction-augmented LCS is both feasible and improves LCS uptake.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 23520 (estimated)
- First submitted
- 30 Jul 2024
- Start date
- 1 Jun 2026
- Primary completion date
- 5 Mar 2029
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Lung cancer
- NCT number
- NCT06538636
What you commit to
- Study type: Interventional
- Planned participants: 23520
- From 1 Jun 2026 to the primary completion date, 5 Mar 2029
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Veterans who have previously undergone lung cancer screening, are diagnosed with lung cancer, or who do not meet eligibility criteria outlined above
Who the study is looking for
- Veterans assigned a PCP at a participating site and who meet inclusion criteria at any point during the study timeframe will be enrolled into the trial. There will be two paths to patient inclusion:
- meeting USPSTF eligibility criteria for LCS, as currently encoded in the background logic of LCS clinical reminders maintained by the VA National Center for Lung Cancer Screening (i.e., age 50-80 years; smoked 20 pack-years; current smoking or quit \<15 years ago) OR
- predicted benefit calculated using LYFS-CTVA model exceeds a stringent high-benefit threshold of life-year gains with annual LCS, as recommended in the 2021 CHEST LCS guidelines
Age in the registry: 50 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Ann Arbor Healthcare System, Ann Arbor, MI Coordinator of this site? Confirm its status | Ann Arbor | United States | Not yet recruiting |
| VA Bedford HealthCare System, Bedford, MA Coordinator of this site? Confirm its status | Bedford | United States | Not yet recruiting |
| VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA Coordinator of this site? Confirm its status | Boston | United States | Not yet recruiting |
| Ralph H. Johnson VA Medical Center, Charleston, SC Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.