NCT06540417Completed
Study of the Effects of the Non-invasive Trigeminal Nerve Stimulation on Ischemic Stroke Patients
Study of the Neuroprotection and Rehabilitation Promotion of the Non-invasive Trigeminal Nerve Stimulation on Ischemic Stroke Patients
Source: ClinicalTrials.gov · Last updated 20 Jul 2025
Brief summary (registry, in English)
In patients with ischemic stroke, the primary focus revolves around enhancing the neuroprotective and rehabilitative effects of external trigeminal nerve stimulation (eTNS) and elucidating its underlying central mechanisms. Through clinical trials and neuroimaging studies, this research endeavors to 1) investigate the clinical impact of TNS on brain protection and 2) rehabilitation acceleration in ischemic stroke patients, while concurrently exploring the potential central nervous mechanisms involved. The ultimate aim is to contribute a novel therapeutic approach to the clinical management of acute ischemic stroke.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 24 Jul 2024
- Start date
- 25 Jul 2024
- Primary completion date
- 1 Oct 2024
- Lead sponsor
- Xidian University
- Diseases
- Stroke
- NCT number
- NCT06540417
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 25 Jul 2024 to the primary completion date, 1 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or recent participation in other neuromodulation stimulation therapies within the past 3 months;
Other illness
- History of ischemic or hemorrhagic stroke within the past 3 months;
- Any other life-threatening or severe medical condition that may interfere with the completion of the study protocol, including the 3-month follow-up;
Lab values
- Severe allergic reaction to MR contrast agents or renal impairment, eGFR \<30 ml/min, excluding the use of contrast agents;
Other
- Patients in a comatose state;
- Pregnant or breastfeeding women;
- Exclusion from trigeminal nerve stimulation: patients with trigeminal neuralgia or facial pain;
- Refusal to sign the informed consent form;
- Presence of contraindications related to MRI scanning.
Who the study is looking for
- Age over 18 years;
- Medically diagnosed with acute ischemic stroke;
- Ability to receive trigeminal nerve stimulation within 72 hours post-stroke onset;
- NIHSS (National Institutes of Health Stroke Scale) score ≥ 4;
- Signed informed consent form;
- Ability and willingness to comply with the study requirements.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xidian University Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.