Fact CheckerSign in

NCT06541015Recruiting

Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients

TENS (Transcutaneous Electrical Nerve Stimulation): Effect of Transcutaneous Spinal Direct Current Stimulation on Lower Limb Reflex, Volitional, and Functional Movement Post-stroke

Source: ClinicalTrials.gov · Last updated 30 Mar 2026

Brief summary (registry, in English)

The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing functional movement in response to a trip event and cross-tilt walking adaptation pattern, as part of their participation in the research study. The estimated amount of time to enroll and collect the data for each of the subjects is four months' time. The data will be analyzed and ready for grant preparation (if successful) in approximately four months after the start of the study.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
100 (estimated)
First submitted
2 Aug 2024
Start date
Jun 2019
Primary completion date
Dec 2026
Lead sponsor
University of Texas Southwestern Medical Center
Diseases
Stroke
NCT number
NCT06541015

What you commit to

  • Study type: Interventional
  • Planned participants: 100
  • From Jun 2019 to the primary completion date, Dec 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Presence of concurrent severe medical illness including unhealed pressure sore, active or untreated infection, thromboembolic disease, severe contracture, osteoporosis, heterotropic classification, lower limb fracture, severe pulmonary disease or cardiovascular instability, uncontrolled seizure, uncontrolled diabetes
  • Has received a Botox injection in the lower extremity within the last 4 months
  • History of prior injury or surgery to the hip or knee
  • Actively taking medications with agents known to increase (e.g. amphetamines) or decrease motor system excitability
  • Presence of concurrent severe medical illness including unhealed pressure sore, active or untreated infection, thromboembolic disease, severe contracture, osteoporosis, heterotropic classification, lower limb fracture, severe pulmonary disease or cardiovascular instability, uncontrolled seizure, uncontrolled diabetes
  • Taking any medication affecting change in CNS
  • History of prior injury or surgery to the hip or knee
  • Actively taking medications with agents known to increase (e.g. amphetamines) or decrease motor system excitability
  • Has received a Botox injection in the lower extremity within the last 4 months

Other illness

  • History of any neurological injury other than a single stroke
  • Presence of significant lower extremity edema - Presence of cardiac pacemaker or any other electrically implanted device - Use of braces limiting harness/Lokomat fit (Any spinal orthoses such as TLSO, HALO)
  • Clinically significant depression, psychiatric disorders, or ongoing drug abuse
  • History of any neurological injury
  • Presence of significant lower extremity edema - Presence of cardiac pacemaker or any other electrically implanted device - Use of braces limiting harness/Lokomat fit (Any spinal orthoses such as TLSO, HALO)
  • Clinically significant depression, psychiatric disorders, or ongoing drug abuse

Other

  • Any cognitive deficit that would prevent informed consent or ability to perform the experiment
  • Weight greater than 300 pounds
  • Adults unable to consent, infants, children, teenagers, pregnant women and prisoners will not be included in the study
  • Suffered a concussion in the last 6 months.
  • Unexplained headaches
    • Healthy Cohort:
  • Any cognitive deficit that would prevent informed consent or ability to perform the experiment
  • Weight greater than 300 pounds
  • Adults unable to consent, infants, children, teenagers, pregnant women and prisoners will not be included in the study
  • Suffered a concussion in the last 6 months.
  • Unexplained headaches

Who the study is looking for

  • History of single unilateral stroke with subsequent lower limb hemiparesis on either side (\> 6 months since onset)
  • Ability to walk as part of activities of daily living
  • Age between 18 and 80
  • No history of stroke, cerebral palsy, injury or surgery to the lower limb.
  • Currently not taking any central nervous system (CNS) affecting medication.
  • Ability to walk as part of activities of daily living
  • Age between 18 and 80

Criteria the registry did not label

  • Post Stroke Cohort:

Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University of Texas Medical Center
Coordinator of this site? Confirm its status		DallasUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.