NCT06556368Active, not recruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK
A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Three-arm Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tarcocimab Tedromer and Tabirafusp Tedromer Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)
Source: ClinicalTrials.gov · Last updated 29 Apr 2026
Brief summary (registry, in English)
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants with Neovascular (Wet) Age-related Macular Degeneration (wAMD)
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 675 (estimated)
- First submitted
- 12 Aug 2024
- Start date
- 23 Aug 2024
- Primary completion date
- Aug 2026
- Lead sponsor
- Kodiak Sciences Inc
- Diseases
- Macular degeneration
- NCT number
- NCT06556368
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 675
- From 23 Aug 2024 to the primary completion date, Aug 2026
- 72 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- BCVA of hand motion or worse in the non-Study Eye or non-physical presence of a non-Study Eye (i.e., monocular)
- Fibrosis or atrophy of \>50% of the lesion size and/or involving the foveal center of the Study Eye at Screening
Who the study is looking for
- Active, treatment-naïve choroidal neovascularization (CNV) secondary to AMD, including subfoveal, juxtafoveal, and extrafoveal lesions, or retinal angiomatous proliferations (RAP) lesions with a CNV component that affects the central subfield, as evidenced by FA or OCT in the Study Eye at Screening
- BCVA ETDRS score between 78 and 25 letters (Snellen equivalent \~20/32 and 20/320) inclusive, in the Study Eye at screening and reconfirmed at Day 1.
- Capable of giving signed informed consent.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (72)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emanuelli Research & Development Center, LLC Coordinator of this site? Confirm its status | Arecibo | Puerto Rico | Unknown status |
| Retina Research Institute of Texas Coordinator of this site? Confirm its status | Abilene | United States | Unknown status |
| Palmetto Retina Center Coordinator of this site? Confirm its status | Aiken | United States | Unknown status |
| Panhandle Eye Group, LLP. - Southwest Retina Specialists Coordinator of this site? Confirm its status | Amarillo | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Asheville Eye Associates Coordinator of this site? Confirm its status | Asheville | United States | Unknown status |
| Southeast Retina Center Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| Austin Retina Associates, PLLC Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Austin Research Center for Retina Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| The Retina Care Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Charleston Neuroscience Institute, LLC Coordinator of this site? Confirm its status | Beaufort | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Pacific Northwest Retina Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Ophthalmic Consultants of Boston Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Star Vision Research Coordinator of this site? Confirm its status | Burleson | United States | Unknown status |
| Midwest Eye Institute Coordinator of this site? Confirm its status | Carmel | United States | Unknown status |
| Associated Vitreoretinal and Uveitis Consultants LLC Coordinator of this site? Confirm its status | Carmel | United States | Unknown status |
| North Carolina Retina Associates Coordinator of this site? Confirm its status | Cary | United States | Unknown status |
| Charleston Neuroscience Institute, LLC Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Blue Ocean Clinical Research Coordinator of this site? Confirm its status | Clearwater | United States | Unknown status |
| Retina Consultants of Southern Colorado Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Retina Consultants of Minnesota Coordinator of this site? Confirm its status | Edina | United States | Unknown status |
| Retina Associates, Ltd. Coordinator of this site? Confirm its status | Elmhurst | United States | Unknown status |
| Erie Retina Research Coordinator of this site? Confirm its status | Erie | United States | Unknown status |
| Retina Group of Florida Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| National Ophthalmic Research Institute Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Retina Consultants of Orange County Coordinator of this site? Confirm its status | Fullerton | United States | Unknown status |
| Charles Retina Institute Coordinator of this site? Confirm its status | Germantown | United States | Unknown status |
| Associated Retina Consultants Coordinator of this site? Confirm its status | Gilbert | United States | Unknown status |
| Global Research Management, Inc. - Lugene Eye Institute Coordinator of this site? Confirm its status | Glendale | United States | Unknown status |
| Piedmont Retina Specialist Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| Cumberland Valley Retina Consultants Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Long Island Vitreoretinal Consultants Coordinator of this site? Confirm its status | Hauppauge | United States | Unknown status |
| Retina Consultants of Nevada Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Graystone Eye Coordinator of this site? Confirm its status | Hickory | United States | Unknown status |
| Texas Retina Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | Katy | United States | Unknown status |
| Charleston Neuroscience Institute LLC Coordinator of this site? Confirm its status | Ladson | United States | Unknown status |
| Retina Vitreous Surgeons of CNY, PC Coordinator of this site? Confirm its status | Liverpool | United States | Unknown status |
| Piedmont Eye Center Coordinator of this site? Confirm its status | Lynchburg | United States | Unknown status |
| Mississippi Retina Associates Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| Retinal Consultants Medical Group, Inc Coordinator of this site? Confirm its status | Modesto | United States | Unknown status |
| Charleston Neuroscience Institute Coordinator of this site? Confirm its status | Mt. Pleasant | United States | Unknown status |
| Illinois Retina Associates Coordinator of this site? Confirm its status | Oak Park | United States | Unknown status |
| California Eye Specialists Medical Group, Inc. Coordinator of this site? Confirm its status | Pasadena | United States | Unknown status |
| Vision Research Solutions PLLC Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Associated Retina Consultants Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Texas Retina Associates Coordinator of this site? Confirm its status | Plano | United States | Unknown status |
| Retina Northwest Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| California Eye Specialists Medical Group, Inc. Coordinator of this site? Confirm its status | Redlands | United States | Unknown status |
| Retina Associates of Western NY Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Austin Retina Associates, PLLC Coordinator of this site? Confirm its status | Round Rock | United States | Unknown status |
| Retinal Consultants Medical Group, Inc. Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Retina Consultants of Minnesota Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Retinal Consultants of Houston dba Retina Consultants of Texas Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Retina Group of Florida Coordinator of this site? Confirm its status | Sarasota | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | Schertz | United States | Unknown status |
| Retina Macula Institute of Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| Ophthalmology Ltd. Coordinator of this site? Confirm its status | Sioux Falls | United States | Unknown status |
| Spokane Eye Clinical Research Coordinator of this site? Confirm its status | Spokane | United States | Unknown status |
| Cascade Medical Research Institute Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| The Retina Institute Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | The Woodlands | United States | Unknown status |
| Retina Associates SW Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| North Carolina Retina Associates Coordinator of this site? Confirm its status | Wake Forest | United States | Unknown status |
| Retina Group of New England, PC Coordinator of this site? Confirm its status | Waterford | United States | Unknown status |
| Eye Clinic of Wisconsin Coordinator of this site? Confirm its status | Wausau | United States | Unknown status |
| Palmetto Retina Center Coordinator of this site? Confirm its status | West Columbia | United States | Unknown status |
| Strategic Clinical Research Group, LLC Coordinator of this site? Confirm its status | Willow Park | United States | Unknown status |
| Western Carolina Clinical Research, LLC Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
| Center for Retina and Macular Disease Coordinator of this site? Confirm its status | Winter Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.