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NCT06560749Recruiting

Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder

Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder: a Controlled and Randomized Study

Source: ClinicalTrials.gov · Last updated 16 Jul 2026

Brief summary (registry, in English)

The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables. Our specific goals are: 1. Evaluate the effect of PE on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with BD who present cognitive impairments in these domains. 2. To evaluate the effect of PE on the quality of life and functionality of patients diagnosed with BD, as well as possible associations with cognitive functions. 3. To evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
72 (estimated)
First submitted
13 Aug 2024
Start date
20 Aug 2024
Primary completion date
Aug 2027
Lead sponsor
Beny Lafer
NCT number
NCT06560749

What you commit to

  • Study type: Interventional
  • Planned participants: 72
  • From 20 Aug 2024 to the primary completion date, Aug 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Alcohol or drug abuse in the last 6 months

Other illness

  • Organic mental disorder

Other

  • BMI \> 40
  • Use of benzodiazepines or beta-blockers in the last month

Who the study is looking for

  • Diagnosis of Bipolar disorder (BD) I and II according to DSM-5
  • Age: 18 - 55 years old
  • Complete primary education
  • Euthymic (YMRS \< 8 and MADRS \< 12)
  • Presence of cognitive impairments (COBRA \> 14 and SCIP \< 75)
  • Estimated IQ ≥ 80
  • No medication changes in the last month
  • Having been without regular PE practice for six months
  • Signature of the TCLE

Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Gabriel Okawa Belizario
Coordinator of this site? Confirm its status
São PauloBrazilRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.