NCT06571175Completed
Quantification of Myocardial Fibrosis in Aortic Stenosis
Myocardial Fibrosis With High Frame Rate Echocardiography in Patients With Aortic Stenosis - A Follow-up Study
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
This study is a long term follow-up of patients that were included as part of a previous study (NCT03422770), where patients with aortic stenosis and healthy controls went through echocardiography, cardiac MRI, long-term ECG-recording, blood tests and quality of life assessment. Echocardiography included high frame ultrasound for detection of natural mechanical waves, and the measured speed of these waves were used as a marker of the extent of myocardial fibrosis. Up to five years have now passed since inclusion at baseline, and a proportion of the patients in the cohort have undergone aortic valve replacement at some point. In this study, the investigators will repeat the cardiac imaging (echocardiography and cardiac MRI), ECG and blood test, to assess long-term changes in myocardial fibrosis in aortic stenosis patients.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 79 (actual)
- First submitted
- 10 Jul 2024
- Start date
- 21 Jan 2025
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Norwegian University of Science and Technology
- Diseases
- Heart failure
- NCT number
- NCT06571175
What you commit to
- Study type: Observational
- Participants enrolled: 79
- From 21 Jan 2025 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previously myocardial infarction (ECG, echocardiogram or hospital record)
Other illness
- Renal insufficiency
- Severe valvular heart disease (except patients)
- Other cardiac disease known to cause myocardial fibrosis
- Severe hypertension
- Other medical conditions deterring protocolled investigation and follow-up
- Other medical conditions affecting 5-years prognosis (cancer, pulmonary disease)
Other
- Severely reduced image-quality (echocardiography and MRI)
Who the study is looking for
- Part of the initial cohort that were included in the baseline study
- Still able to undergo protocolled investigations
- Patients: Mild, moderate or severe AS
Age in the registry: 18 years to 90 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Olavs Hosptial Coordinator of this site? Confirm its status | Trondheim | Norway | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.