NCT06576089Recruiting
Optimizing Recruitment to Drive Equitable Research Opportunity in Stroke Rehabilitation Trials in Canada
Optimizing Recruitment to Drive Equitable Research Opportunity in Stroke Rehabilitation in Canada - The ORDER Pilot Study
Source: ClinicalTrials.gov · Last updated 26 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Stroke is a major health issue in Canada. Stroke affects over 400,000 Canadians, and this number is expected to nearly double by 2038. Research studies in stroke recovery can help us better understand effective rehabilitation treatments and help reduce the burden of stroke. Some groups of people however are commonly not included in stroke studies. For example, it is more common for men to take part in research than women, and people with aphasia (a language impairment commonly seen after stroke) are often excluded from studies. Also, deciding whether to even take part in a research study can be difficult and overwhelming, especially in the early days after stroke, leaving many people to decline to participate. Research has shown that women experience different barriers to participating in stroke research than men. This means that research findings, and the decisions made during stroke care based on these findings, may not reflect the true stroke population. Better ways to help support groups like women and people with aphasia to participate in stroke research are needed, so that study findings will better represent people living with stroke.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 21 Aug 2024
- Start date
- 16 Jun 2025
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- McMaster University
- Diseases
- Stroke
- NCT number
- NCT06576089
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 16 Jun 2025 to the primary completion date, 30 Jun 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently taking any of the following anticonvulsant medications: Carbamazepine, Phenobarbital, Phenytoin
- Currently taking any of the following antifungal and/or antibacterial medications: Ketoconazole, Itraconazole, Voriconazole, Rifampin, Clarithromycin, Rifabutin + Protease Inhibitor
- Currently taking St. John's Wort
Other illness
- Pre-stroke modified Rankin score ≥2
- Limited resources or illness that will not enable a return to living outside of a facility
- History of dementia
- Cancer or other chronic illness that makes 1-year survival unlikely or will detract from the ability to carry out exercise and skills practice
- Existing pre-stroke serious disabling disease (e.g., Parkinson's disease, severe traumatic brain injury, amputation)
- Seizure related to stroke
- Acute or chronic epilepsy
- Known HIV positivity
Lab values
- History of hepatitis or elevated hepatic transaminases or bilirubin
- History of renal insufficiency or creatinine clearance (eGFR) \<60mL / min / 1.73m2
Other
- Pregnant, breastfeeding, or positive test for pregnancy at baseline
- Women of childbearing potential who are not using one highly effective form of contraception or two forms of effective contraception
Who the study is looking for
- Primary ischemic anterior circulation stroke
- Age ≥18 years
- ≥5 days but \<8 weeks after stroke on the date of medication (Maraviroc or placebo) start
- Hemiparesis requiring inpatient rehabilitation
- Assistance available for daily rehabilitation training practice and for transportation when needed
- Adequate language skills to understand Informed Consent and retain information during daily therapies
- At least one of the following: some shoulder abduction with gravity eliminated and visible extension in two or more digits OR visible hip flexion or extension
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Calgary- Foothills Medical Centre Coordinator of this site? Confirm its status | Calgary | Canada | Recruiting |
| Dalhousie University Coordinator of this site? Confirm its status | Halifax | Canada | Recruiting |
| Parkwood Institute Coordinator of this site? Confirm its status | London | Canada | Recruiting |
| Toronto Rehabilitation Institute - University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Not yet recruiting |
| University of British Columbia & GF Strong Rehabilitation Centre Coordinator of this site? Confirm its status | Vancouver | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.