NCT06576518Completed
Exercise Intervention in Patients With Metabolic Syndrome and Renal Disease: a Prospective Study
Exercise Intervention in Patients With Metabolic Syndrome and Renal Disease: a Prospective Study (EXRED)
Source: ClinicalTrials.gov · Last updated 28 Aug 2024
Brief summary (registry, in English)
INTRODUCTION: Obesity (OB) and metabolic syndrome (MetS) are risk and progression factors for chronic kidney disease (CKD). However, the effect of OB/MetS intervention with exercise on renal function progression and proteinuria is unknown. OBJECTIVE: To analyse the effect of therapeutic exercise on MetS and main renal outcomes in patients with CKD. METHODOLOGY: This is a 6-month prospective exploratory study. Patients with stablished CKD (1-4) and MetS were treated with individualised incremental exercise (aerobic and resistance). Simultaneously, a plan of adherence was set up to promote compliance. Renal and metabolic outcomes were collected. The main renal parameters were: proteinuria, in isolated urine samples, and glomerular filtration rate (GFR), measured by iohexol DBS, at 0, 3 and 6 months. At the same time points, metabolic outcomes were measured: weight, dyslipidemia, insulin resistance and hypertension.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 50 (actual)
- First submitted
- 23 Aug 2024
- Start date
- 10 Jun 2021
- Primary completion date
- 2 Dec 2021
- Lead sponsor
- University of La Laguna
- Diseases
- Chronic kidney disease, Obesity
- NCT number
- NCT06576518
What you commit to
- Study type: Interventional
- Participants enrolled: 50
- From 10 Jun 2021 to the primary completion date, 2 Dec 2021
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- clinical conditions that exclude exercise therapy such as clinical instability, active infection, cancer, acute cardiovascular disease, advanced CKD, pulmonary hypertension, or limb amputations
- severe psychiatric illness
- allergy to iodine
Other
- inability to understand the protocol
Who the study is looking for
- age \>18 years
- CKD of diverse aetiologies
- estimated GFR ≥ 30 ml/min
- BMI ≥ 27 kg/m2 associated to MetS or diabetes mellitus (DM)
- stable renal function for at least 6 months before screening
- ability to perform exercise
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universidad de La Laguna Coordinator of this site? Confirm its status | San Cristóbal de La Laguna | Spain | Unknown status |
Related publications
- Exercise Intervention in Patients with Metabolic Syndrome and Renal Disease: A Prospective Study (EXRED).Nephron · 2026 · PMID 41308049
This page is information, not medical advice. Discuss any trial with your doctor.