NCT06578117Active, not recruiting
Statistical Learning as a Novel Intervention for Cortical Blindness
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
This project aims to develop a novel visual training paradigm for use in visually-intact participants and those sufferings from stroke-induced visual impairments. Our task design is built upon theories of statistical learning to reduce the overall training burden while still producing profound improvements to visual abilities. Efficacy will be first established in visually-intact controls before testing in stroke survivors to assess the feasibility of this form of learning in the damaged visual system.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 27 Aug 2024
- Start date
- 6 Nov 2024
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- University of Rochester
- Diseases
- Stroke
- NCT number
- NCT06578117
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 6 Nov 2024 to the primary completion date, 1 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently taking neuroactive medications which would impact training, as determined by PI
Other illness
- Past or present ocular disease interfering with visual acuity
- History of traumatic brain injury
- Documented history of drug/alcohol abuse
- Cognitive or seizure disorders
- Those who are suffering from an active disease process involving their nervous system.
- Presence of cognitive or seizure disorders
- Presence of visual field loss from ocular disease or disorder
Other
- Best corrected visual acuity (BCVA) worse than 20/40 in either eye
- Sustained documented or suspected damage to the dorsal Lateral Geniculate Nucleus
- Presence of diffuse whole brain degenerative processes
- Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures
- One-sided attentional neglect
- Those who lack the competence or are otherwise unable to perform the visual training exercises as directed.
- Control participants
- Any damage to the visual system
- Best corrected visual acuity worse than 20/40 in either eye
Who the study is looking for
- Between 21 and 75 years of age
- Residents of the United States or Canada
- Have successfully completed previous enrollment in Dr. Huxlin study (IRB #5966 or #75)
- Exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
- Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey visual fields. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
- Able to fixate on visual targets reliably for 1000ms within 1-deg of visual angle.
- Willing, able, and competent to provide their own informed consent
- Normal cognitive abilities and be able to understand written and oral instructions in English
- Between 21 and 75 years of age
- No history of neurological disorder.
- Competent and responsible, as determined by the screening interview
Criteria the registry did not label
- Cortically Blind participants
Age in the registry: 21 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Rochester Medical Center Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.