NCT06579807Recruiting
Cardiac Rehabilitation and Coronary Artery Disease
Effect of a Cardiovascular Rehabilitation Program on Atherosclerosis, Endothelial Function and Inflammation in Patients With Coronary Artery Disease
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
Patients with coronary artery disease (CAD) aged 40-70 years will undergo exercise training (thrice weekly for 12 weeks). A reference group composed of healthy individuals will be included. Evaluations will be conducted at baseline and after the intervention period during two visits. During the first visit, carotid artery thickness will be assessed via ultrasound before and after a cardiopulmonary exercise testing. The second visit will include the evaluation of endothelial function using venous occlusion plethysmography. After this, participants will engage in 30 minutes of moderate-intensity aerobic exercise, and blood samples will be collected pre- and post-exercise. Circulating levels of kynurenine pathway (KP) metabolites (Tryptophan, kynurenine, kynurenic acid, and quinolinic acid), pro-inflammatory cytokines, cell adhesion molecules, and lipid profiles will be measured via Enzyme-Linked Immunosorbent Assay (ELISA), multiplex essays, and biochemical analysis; respectively.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 27 Aug 2024
- Start date
- 1 Oct 2024
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
- Diseases
- Coronary artery disease
- NCT number
- NCT06579807
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 1 Oct 2024 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- diagnosis of heart failure, pulmonary disease, Chagas disease, or tuberculosis
Other
- regular physical exercise practice (≥ 3 days/week for 30 min) over the past 6 months
- malnutrition (body mass index \[BMI\] \< 18.5 kg/m²)
- smoking
- obesity (BMI ≥ 30 kg/m²)
Who the study is looking for
- Eligible CAD patients will be those aged 40 to 70 years, of both sexes, entering the cardiac rehabilitation program at HUPE. CAD will be defined as any acute coronary syndrome, including myocardial infarction with and without ST-segment elevation, and unstable angina (all defined by characteristic histories, electrocardiographic abnormalities, and cardiac enzyme abnormalities), or obstructive CAD diagnosed via coronary angiography (defined as ≥ 50% stenosis of any epicardial coronary artery) in patients with stable angina.
- Healthy controls: adults aged 40 to 70 years, of both sexes, without CAD evidence.
Age in the registry: 40 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rio de Janeiro State University Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.