Magnetic Seizure Therapy for Psychotic Disorders

Prior treatment

• (1) have a concomitant severe medical illness;
• (8) have an intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed;

Other illness

• (3) have a history of DSM-5 diagnosis of substance dependence or abuse within the past three months;
• (4) history of traumatic brain injury (with a screening scale score of 7 or above);
• (5) history of poor response to electroconvulsive therapy or MST;
• (6) have probable dementia based on study investigator assessment; have any significant neurological disorder or condition likely to be associated with increased intracranial pressure or a space occupying brain lesion, e.g., cerebral aneurysm;

Lab values

• (7) presenting with a medical condition, medication, or laboratory anomaly deemed by the investigator to potentially induce psychotic symptoms, or significant cognitive impairment. (e.g., hypothyroidism with low TSH, rheumatoid arthritis requiring high dose prednisone, or Cushing's disease);

Other

• (2) are pregnant or intend to get pregnant during the study;
• (9) a score of 18 or more on the 24-item Hamilton Depression Rating Scale (HAM-D);
• (10) needing ECT treatment immediately due to such dangerous symptoms as suicide, stupor or psychomotor agitation, etc.

• (1) meets the diagnostic criteria for schizophrenia or other primary psychotic disorders according to DSM-5;
• (2) age range between 18 and 55 years;
• (3) Positive And Negative Syndrome Scale (PANSS) score≥60;
• (4) to provide informed consent.