NCT06583863Completed
Parasitic Infections and Ulcerative Colitis: Combining Anti-parasitic and Immunomodulatory Treatments May Achieve Remission
Parasitic Infection Flares up the Activity of Ulcerative Colitis; However, Combined Immunomodulatory Therapy With Anti-parasitic Treatment Could Proceed Toward Remission
Source: ClinicalTrials.gov · Last updated 4 Sept 2024
Brief summary (registry, in English)
The study aimed to explore the link between parasitic infections and the severity of ulcerative colitis (UC). 120 UC patients were divided into three groups: those without infection, those with Giardia lamblia infection treated with metronidazole, and those with Giardia infection treated with a combination of metronidazole and E. purpurea. The results revealed that patients with Giardia infections exhibited more severe UC symptoms. All groups experienced improved symptoms following treatment, but the combination therapy group demonstrated the most significant improvement. Remission rates were highest in the group without infection and the group receiving combination therapy. Additionally, the study identified E. purpurea therapy and a substantial reduction in SCCAI score as significant predictors of higher remission rates.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 120 (actual)
- First submitted
- 2 Sept 2024
- Start date
- 12 Sept 2023
- Primary completion date
- 1 Apr 2024
- Lead sponsor
- Benha University
- Diseases
- Ulcerative colitis
- NCT number
- NCT06583863
What you commit to
- Study type: Interventional
- Participants enrolled: 120
- From 12 Sept 2023 to the primary completion date, 1 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who were maintained on immunosuppressant therapy,
Other illness
- Patients had Inflammatory Bowel Disease other than Ulcerative Colitis,
- Patients had multiple parasitic infections,
- Patients had infection by parasites other than G. lambellia,
Other
- Patients who were in remission and patients refused to sign the written consent to participate in the study.
Who the study is looking for
- Ulcerative Colitis patients had active disease,
- Patients had parasitic infection by G. lambellia,
- Patients free of parasitic infection,
- Patients free of exclusion criteria..
Age in the registry: 20 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Benha Faculty of Medicine Coordinator of this site? Confirm its status | Banhā | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.