NCT06584448Recruiting
Drinking, Acetate, and Stress
Role of Acetate in Heavy Drinking
Source: ClinicalTrials.gov · Last updated 12 Aug 2026
Brief summary (registry, in English)
The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 30 Aug 2024
- Start date
- 6 Nov 2024
- Primary completion date
- Jan 2029
- Lead sponsor
- Yale University
- NCT number
- NCT06584448
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 6 Nov 2024 to the primary completion date, Jan 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- A positive test result at intake appointment and subsequent appointments on urine drug screens conducted for illicit drugs. (Note: participants will not be paid for study visits if they test positive for an illicit drug and will be immediately excluded from study).
- Recent taking of medications that may influence study outcomes (e.g., disulfiram, naltrexone, acamprosate, anticonvulsants).
Other illness
- Subjects with any significant current medical conditions (neurological, cardiovascular, endocrine, thyroid, renal, liver), seizures (for LTS subjects only- seizures directly related to alcohol detoxification are not an exclusion) , delirium or hallucinations, or other unstable medical conditions, including HIV.
- Current DSM-5 substance use disorder (other than AUD or tobacco use disorder)
Other
- Any metallic objects implanted in their body which would make imaging unsafe (pacemaker, etc)
- Claustrophobia, or other inability to participate in an MRI
- Women who are pregnant or nursing. Women who have an IUD that would make imaging unsafe.
- Subjects likely to exhibit clinically significant alcohol withdrawal during the study.
Who the study is looking for
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Medically stable male or female, aged 18-55.
- Able to read, write and complete a multitude of self-assessments in English
- Meets DSM-5 criteria for current Alcohol Use Disorder (AUD)
- Participants who have Alcohol Use Disorder and are actively drinking must be willing to receive (at no cost) inpatient treatment for AUD for a period of up to 30 days. Participants who have been treated for an Alcohol Use Disorder and are now sober three months or longer will NOT be required to go inpatient.
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Anlyan Center, 300 Cedar St. Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.