NCT06584916CompletedPhase 3
A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)
A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Orforglipron Once Daily Versus Placebo for Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
Source: ClinicalTrials.gov · Last updated 4 Jun 2026
Brief summary (registry, in English)
The main purpose of this study is to evaluate the efficacy and safety of orforglipron on maintenance of body weight reduction in participants who previously completed treatment with injectable tirzepatide (Zepbound) or injectable semaglutide (Wegovy) in the SURMOUNT-5 trial (NCT05822830).
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 376 (actual)
- First submitted
- 3 Sept 2024
- Start date
- 13 Sept 2024
- Primary completion date
- 21 Nov 2025
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity
- NCT number
- NCT06584916
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 376
- From 13 Sept 2024 to the primary completion date, 21 Nov 2025
- 29 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a prior or planned surgical treatment for obesity
Other illness
- Have Type 1 Diabetes, Type 2 Diabetes, or any other types of diabetes, history of ketoacidosis, or hyperosmolar state/coma
- Have acute or chronic hepatitis
- Have a history of acute or chronic pancreatitis
Who the study is looking for
- Have completed the SURMOUNT-5 study (NCT05822830; a trial of injectable tirzepatide \[Zepbound\] versus injectable semaglutide \[Wegovy\]) on study treatment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (29)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Puerto Rico Medical Research Coordinator of this site? Confirm its status | Ponce | Puerto Rico | Unknown status |
| Wellness clinical Research Vega Baja Coordinator of this site? Confirm its status | Vega Baja | Puerto Rico | Unknown status |
| The University of Texas Health Science Center at Houston Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Cahaba Research Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| WR-ClinSearch, LLC Coordinator of this site? Confirm its status | Chattanooga | United States | Unknown status |
| StudyMetrix Research Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| North Texas Endocrine Center Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Velocity Clinical Research, Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Lillestol Research Coordinator of this site? Confirm its status | Fargo | United States | Unknown status |
| Prime Health and Wellness/SKYCRNG Coordinator of this site? Confirm its status | Fayette | United States | Unknown status |
| PharmQuest Life Sciences LLC Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| Tribe Clinical Research LLC Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Biopharma Informatic, LLC Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| PlanIt Research, PLLC Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Rocky Mountain Clinical Research Coordinator of this site? Confirm its status | Idaho Falls | United States | Unknown status |
| Palm Research Center Sunset Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Palm Research Center Tenaya Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| L-MARC Research Center Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Southern Endocrinology Associates Coordinator of this site? Confirm its status | Mesquite | United States | Unknown status |
| New Horizon Research Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Weill Cornell Medical College Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Alliance for Multispecialty Research, LLC Coordinator of this site? Confirm its status | Norman | United States | Unknown status |
| Cahaba Research - Pelham Coordinator of this site? Confirm its status | Pelham | United States | Unknown status |
| Southern California Dermatology, Inc. Coordinator of this site? Confirm its status | Santa Ana | United States | Unknown status |
| Encompass Clinical Research Coordinator of this site? Confirm its status | Spring Valley | United States | Unknown status |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| University Clinical Investigators, Inc. Coordinator of this site? Confirm its status | Tustin | United States | Unknown status |
| Rophe Adult and Pediatric Medicine/SKYCRNG Coordinator of this site? Confirm its status | Union City | United States | Unknown status |
| Iowa Diabetes and Endocrinology Research Center Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
Related publications
- Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial.Nat Med · 2026 · PMID 42120723
This page is information, not medical advice. Discuss any trial with your doctor.