NCT06588205Recruiting
Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma
Multicenter, Observational, Retrospective-prospective Study Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma
Source: ClinicalTrials.gov · Last updated 29 Dec 2025
Brief summary (registry, in English)
This is a observational, retrospective and prospective study designed to assess the potential correlations between MYC alterations, lymphoma mutational landscape and functional immune contextures in Diffuse Large B-cell Lymphoma or High-Grade B-cell Lymphoma
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 2 Sept 2024
- Start date
- 5 May 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- Fondazione Italiana Linfomi - ETS
- Diseases
- Diffuse large B-cell lymphoma
- NCT number
- NCT06588205
What you commit to
- Study type: Observational
- Planned participants: 200
- From 5 May 2025 to the primary completion date, Dec 2027
- 20 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have received palliative treatment
Other
- Primary lymphomas of the central nervous system, plasmablastic lymphoma, Burkitt's lymphoma, primary mediastinal B lymphoma
Who the study is looking for
- Diagnosis of nodal and extranodal Diffuse Large B Cell Lymphoma, High Grade B Cell Lymphomas (including low-grade transformed lymphomas; double and triple hit; 11q aberration; not otherwise specified) after 1st January 2019
- Presence of one MYC translocation or gain of copies (GCN: \> 3 copies in more than 30% of the nuclei) or amplification evaluated by FISH
- Availability of immunohistochemical analysis of CD10, Bcl6, MUM1, Bcl2, Myc, Ki67
- Have received curative treatment (e.g. R-CHOP, R DA EPOCH, intensified "Burkitt like" chemotherapies) as first-line therapy
- Histological material of adequate size and quality to perform histological review with any additional investigations (immunohistochemistry, FISH and other molecular analysis). A FFPE block must be provided for patient enrollment.
- Age between 18 and 79 years
Age in the registry: 18 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| A.O.U. SS. Antonio e Biagio e C. Arrigo - S.C.D.U. Ematologia Coordinator of this site? Confirm its status | Alessandria | Italy | Recruiting |
| A.O.U. Ospedali Riuniti delle Marche - Clinica di Ematologia Coordinator of this site? Confirm its status | Ancona | Italy | Recruiting |
| I.R.C.C.S. Istituto Tumori Giovanni Paolo II - U.O.C. Ematologia Coordinator of this site? Confirm its status | Bari | Italy | Recruiting |
| ASST Spedali Civili - S.C. Ematologia Coordinator of this site? Confirm its status | Brescia | Italy | Recruiting |
| I.R.C.C.S. Istituto di Candiolo - FPO Coordinator of this site? Confirm its status | Candiolo | Italy | Recruiting |
| I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncoematologia Coordinator of this site? Confirm its status | Castelfranco Veneto | Italy | Not yet recruiting |
| ARNAS Garibaldi - U.O.C. Ematologia Coordinator of this site? Confirm its status | Catania | Italy | Recruiting |
| A.S.T. Macerata - U.O.S.D Ematologia Coordinator of this site? Confirm its status | Civitanova Marche | Italy | Recruiting |
| Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia Coordinator of this site? Confirm its status | Florence | Italy | Recruiting |
| ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Ospedale Maggiore Policlinico Fondazione IRCCS Ca' Granda - S.C. Ematologia Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1 Coordinator of this site? Confirm its status | Padova | Italy | Not yet recruiting |
| A.O.U. di Padova - U.O.C. Ematologia Coordinator of this site? Confirm its status | Padova | Italy | Not yet recruiting |
| AUSL Modena sede di Sassuolo - UOSD di Oncologia Area Sud Coordinator of this site? Confirm its status | Sassuolo | Italy | Recruiting |
| U.O.C. Ematologia - A.O.U. Senese Coordinator of this site? Confirm its status | Siena | Italy | Not yet recruiting |
| A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia U Coordinator of this site? Confirm its status | Torino | Italy | Not yet recruiting |
| ULSS 2 Ospedale Ca' Foncello - U.O.C. Ematologia Coordinator of this site? Confirm its status | Treviso | Italy | Recruiting |
| A.O. Cardinale "G. Panico" - U.O.C Ematologia e Trapianto Midollo Osseo Coordinator of this site? Confirm its status | Tricase | Italy | Recruiting |
| A.S.U. Giuliano Isontina - S.C. Ematologia Coordinator of this site? Confirm its status | Trieste | Italy | Recruiting |
| A.O.U.I. di Verona - Ematologia Coordinator of this site? Confirm its status | Verona | Italy | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.