NCT06593522Active, not recruitingPhase 2
A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
A Phase 2 Study Evaluating the Efficacy, Safety, Tolerability, and Pharmacokinetics of Anvumetostat in Subjects With Methylthioadenosine Phosphorylase (MTAP)-Deleted Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC)
Source: ClinicalTrials.gov · Last updated 28 May 2026
Brief summary (registry, in English)
The main objective of the study is to characterize safety and efficacy of 2 dose levels of anvumetostat by investigator, and to evaluate anvumetostat monotherapy efficacy by Blinded Independent Central Review (BICR).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 61 (actual)
- First submitted
- 3 Sept 2024
- Start date
- 26 Dec 2024
- Primary completion date
- 31 Oct 2026
- Lead sponsor
- Amgen
- Diseases
- Lung cancer
- NCT number
- NCT06593522
- EU CT number
- 2024-514459-14-00
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 61
- From 26 Dec 2024 to the primary completion date, 31 Oct 2026
- 141 sites in 24 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Major surgery within 28 days of study day 1.
Other illness
- Disease Related
- Untreated symptomatic central nervous system (CNS) metastatic disease regardless of size or asymptomatic brain metastases greater than 2 cm per lesion.
Lab values
- Tumors harboring the following mutations amenable to targeted therapies: epidermal growth factor receptor (EGFR), ALK receptor tyrosine kinase (ALK), ROS proto-oncogene 1 (ROS1), neurotrophic tyrosine receptor kinase (NTRK), MET proto-oncogene (MET), B-Raf proto-oncogene (BRAF), RET proto-oncogene (RET), Human epidermal growth factor receptor 2 (HER2/ERBB2), KRAS proto-oncogene G12C (KRAS G12C).
- Other Medical Conditions
Who the study is looking for
- Histologically or cytologically confirmed metastatic or unresectable locally advanced MTAP-deleted (Homozygous deletion of MTAP) NSCLC
- Participants will have received and progressed or experienced disease recurrence on or after receiving at least 1 prior systemic therapy for locally advanced and unresectable or metastatic disease.
- Either an archival tissue sample or an archival block must be available.
- Life expectancy of greater than 3 months, in the opinion of the investigator.
- Participants who have had brain metastases and have been appropriately treated with radiation therapy or surgery ending at least 14 days before study day 1 are eligible.
- Participants with untreated asymptomatic brain metastases smaller or equal to 2 cm in size (per lesion if more than one) and not requiring corticosteroid treatment are eligible.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (141)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cancer Research South Australia Coordinator of this site? Confirm its status | Adelaide | Australia | Unknown status |
| Mater Hospital Brisbane Coordinator of this site? Confirm its status | South Brisbane | Australia | Unknown status |
| GenesisCare -North Shore Oncology Coordinator of this site? Confirm its status | St Leonards | Australia | Unknown status |
| Calvary Mater Newcastle Hospital Coordinator of this site? Confirm its status | Waratah | Australia | Unknown status |
| Antwerp University Hospital Coordinator of this site? Confirm its status | Edegem | Belgium | Completed |
| Universitair Ziekenhuis Gent Coordinator of this site? Confirm its status | Gent | Belgium | Completed |
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Completed |
| Algemeen Ziekenhuis Delta Coordinator of this site? Confirm its status | Roeselare | Belgium | Completed |
| Fundacao pio xII Barretos Coordinator of this site? Confirm its status | Barretos | Brazil | Unknown status |
| Liga Norte Riograndense Contra o Cancer Coordinator of this site? Confirm its status | Natal | Brazil | Unknown status |
| Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Hospital Nossa Senhora da Conceição Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Instituto de Educacao Pesquisa e Gestao em Saude Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| Nucleo de Oncologia da Bahia Coordinator of this site? Confirm its status | Salvador | Brazil | Unknown status |
| Fund Faculdade Regional Med Sao Jose Rio Preto Coordinator of this site? Confirm its status | São José do Rio Preto | Brazil | Unknown status |
| Fundacao Antonio Prudente - Hosp AC Camargo Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Instituto do Cancer Estado SP Icesp Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Centro Paulista de Oncologia Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| William Osler Health System - Brampton Civic Hospital Coordinator of this site? Confirm its status | Brampton | Canada | Unknown status |
| Cross Cancer Institute Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| London Health Sciences Centre Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| McGill University Health Centre Glen Site Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Princess Margaret Cancer Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Universitaetsspital Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Unknown status |
| Hôpitaux universitaires de Genève Coordinator of this site? Confirm its status | Geneva | Switzerland | Unknown status |
| Kantonsspital Sankt Gallen Coordinator of this site? Confirm its status | Sankt Gallen | Switzerland | Unknown status |
| Beijing Cancer Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Beijing chest hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Jilin Cancer Hospital Coordinator of this site? Confirm its status | Changchun | China | Unknown status |
| The Second Xiangya Hospital of Central South University Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| West China Hospital，Sichuan University Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| Mengchao Hepatobiliary Hospital of Fujian Medical University Coordinator of this site? Confirm its status | Fuzhou | China | Unknown status |
| The First Affiliated Hospital Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
| Zhejiang Cancer Hospital Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
| Jinan Central Hospital Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Shanghai East Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| Henan Cancer Hospital Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
| The First Affiliated Hospital of Zhengzhou University Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
| Masarykuv Onkologicky Ustav Coordinator of this site? Confirm its status | Brno-Stred | Czechia | Completed |
| University Hospital Olomouc Coordinator of this site? Confirm its status | Olomouc | Czechia | Completed |
| Vseobecna Fakultni Nemocnice V Praze Coordinator of this site? Confirm its status | Prague 2 | Czechia | Completed |
| Fakultni Thomayerova nemocnice Coordinator of this site? Confirm its status | Prague 4 | Czechia | Completed |
| Technische Universitaet Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Completed |
| Universitaetsklinikum Essen (AoR) Coordinator of this site? Confirm its status | Essen | Germany | Completed |
| LungenClinic Grosshansdorf GmbH Coordinator of this site? Confirm its status | Grosshansdorf | Germany | Completed |
| Thoraxklinik Heidelberg gGmbH Coordinator of this site? Confirm its status | Heidelberg | Germany | Completed |
| Universitaetsklinikum Wuerzburg AöR Coordinator of this site? Confirm its status | Wuerzburg | Germany | Completed |
| Complexo Hospitalario Universitario A Coruña Coordinator of this site? Confirm its status | A Coruña | Spain | Completed |
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Universitario 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario Puerta de Hierro de Majadahonda Coordinator of this site? Confirm its status | Majadahonda | Spain | Completed |
| Hospital Universitario Regional de Málaga Coordinator of this site? Confirm its status | Málaga | Spain | Completed |
| Hospital Universitario Virgen De La Macarena Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| Institut Bergonie Coordinator of this site? Confirm its status | Bordeaux | France | Completed |
| Centre Hospitalier Universitaire de Lille Coordinator of this site? Confirm its status | Lille | France | Completed |
| Centre Hospitalier Regional De Marseille Coordinator of this site? Confirm its status | Marseille | France | Completed |
| Institut Curie Coordinator of this site? Confirm its status | Paris | France | Completed |
| Assistance Publique Hopitaux De Paris Coordinator of this site? Confirm its status | Paris Cedex 18 | France | Completed |
| Institut De Cancerologie De L Ouest Coordinator of this site? Confirm its status | Saint-Herblain Cedex | France | Completed |
| Centre Hospitalier Universitaire de Toulouse Coordinator of this site? Confirm its status | Toulouse | France | Completed |
| Institut Gustave Roussy Coordinator of this site? Confirm its status | Villejuif Cedex | France | Completed |
| Henry Dunant Hospital Center Coordinator of this site? Confirm its status | Athens | Greece | Completed |
| Thoracic General Hospital of Athens "I Sotiria" Coordinator of this site? Confirm its status | Athens | Greece | Completed |
| University General Hospital Attikon Coordinator of this site? Confirm its status | Athens | Greece | Completed |
| Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. Coordinator of this site? Confirm its status | Cholargos | Greece | Completed |
| University General Hospital of Heraklion Coordinator of this site? Confirm its status | Heraklion | Greece | Completed |
| Metropolitan Hospital Coordinator of this site? Confirm its status | Pireas | Greece | Completed |
| Bioclinic S.A. Coordinator of this site? Confirm its status | Thessaloniki | Greece | Completed |
| St. Luke's Hospital S.A. Coordinator of this site? Confirm its status | Thessaloniki | Greece | Completed |
| Queen Mary Hospital, The University of Hong Kong Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
| Prince of Wales Hospital, Chinese University of Hong Kong Coordinator of this site? Confirm its status | Shatin, New Territories | Hong Kong SAR China | Unknown status |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Completed |
| Orszagos Koranyi Pulmonologiai Intezet Coordinator of this site? Confirm its status | Budapest XII | Hungary | Completed |
| Farkasgyepui Tudogyogyintezet Coordinator of this site? Confirm its status | Farkasgyepű | Hungary | Completed |
| Matrai Gyogyintezet Coordinator of this site? Confirm its status | Gyöngyös | Hungary | Completed |
| Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz Coordinator of this site? Confirm its status | Győr | Hungary | Completed |
| Fondazione IRCCS - Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Azienda Ospedaliero-Universitaria San Luigi Gonzaga Coordinator of this site? Confirm its status | Orbassano | Italy | Completed |
| Azienda Ospedaliero Universitaria Pisana Coordinator of this site? Confirm its status | Pisa | Italy | Completed |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Humanitas Mirasole S.p.A. Coordinator of this site? Confirm its status | Rozzano | Italy | Completed |
| Centro Ricerche Cliniche di Verona s.r.l. Coordinator of this site? Confirm its status | Verona | Italy | Completed |
| National Cancer Center Hospital Coordinator of this site? Confirm its status | Chuo Ku | Japan | Unknown status |
| National Cancer Center Hospital East Coordinator of this site? Confirm its status | Kashiwa-shi | Japan | Unknown status |
| The Cancer Institute Hospital of Japanese Foundation for Cancer Research Coordinator of this site? Confirm its status | Koto-ku | Japan | Unknown status |
| Aichi Cancer Center Coordinator of this site? Confirm its status | Nagoya | Japan | Unknown status |
| Shizuoka Cancer Center Coordinator of this site? Confirm its status | Sunto-gun | Japan | Unknown status |
| Wakayama Medical University Hospital Coordinator of this site? Confirm its status | Wakayama | Japan | Unknown status |
| Cha Bundang Medical Center, Cha University Coordinator of this site? Confirm its status | Seongnam-si, Gyeonggi-do | South Korea | Unknown status |
| Severance Hospital, Yonsei University Health System Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Ajou University Hospital Coordinator of this site? Confirm its status | Suwon-si Gyeonggi-do | South Korea | Unknown status |
| The Catholic University of Korea St Vincents Hospital Coordinator of this site? Confirm its status | Suwon-si, Gyeonggi-do | South Korea | Unknown status |
| Pauls Stradins Clinical University Hospital Coordinator of this site? Confirm its status | Riga | Latvia | Completed |
| Rigas Austrumu kliniska universitates slimnica SIA Coordinator of this site? Confirm its status | Riga | Latvia | Completed |
| Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Completed |
| Ziekenhuis St Jansdal Coordinator of this site? Confirm its status | Harderwijk | Netherlands | Completed |
| Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Completed |
| Wojewodzki Szpital Specjalistyczny Nr 4 W Bytomiu Samodzielny Publiczny Zaklad Opieki Zdrowotnej Coordinator of this site? Confirm its status | Bytom | Poland | Completed |
| Futuremeds Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow Coordinator of this site? Confirm its status | Poznan | Poland | Completed |
| Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| National Institute Of Tuberculosis And Lung Diseases Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| CCAB Centro Clinico Academico Braga Associacao Coordinator of this site? Confirm its status | Braga | Portugal | Active, not recruiting |
| Champalimaud Clinical Centre Coordinator of this site? Confirm its status | Lisbon | Portugal | Active, not recruiting |
| Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Active, not recruiting |
| Hospital CUF Porto S.A. Coordinator of this site? Confirm its status | Porto | Portugal | Active, not recruiting |
| National Cancer Centre Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| National University Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| Taichung Veterans General Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
| National Cheng Kung University Hospital Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Trinity Health Saint Joseph Mercy Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Texas Oncology - Central/South Texas Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Our Lady of the Lake Cancer Institute Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| Sarah Cannon Research Institute Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Texas Oncology - Dallas Fort Worth Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Rocky Mountain Cancer Centers Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| City of Hope Orange County Lennar Foundation Cancer Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| City of Hope National Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Virginia Cancer Specialists PC Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Cancer and Hematology Centers of Western Michigan Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| US Oncology Research Investigational Products Center Coordinator of this site? Confirm its status | Irving | United States | Unknown status |
| University of California, Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Valkyrie Clinical Trials Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| United States Oncology Regulatory Affairs Corporate Office Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Sarah Cannon Research Institute - Oncology Partners Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Eastern Connecticut Hematology and Oncology Associates Coordinator of this site? Confirm its status | Norwich | United States | Unknown status |
| Hartford HealthCare Cancer Institute - Manchester Coordinator of this site? Confirm its status | Plainville | United States | Unknown status |
| Texas Oncology - Northeast Texas Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| MedStar Georgetown University Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| Adana Sehir Egitim ve Arastirma Hastanesi Coordinator of this site? Confirm its status | Adana | Turkey (Türkiye) | Unknown status |
| Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Ankara Bilkent Sehir Hastanesi Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Memorial Bahcelievler Hastanesi Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
| Bagcilar Medipol Mega Universite Hastanesi Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.