NCT06595680Not yet recruitingPhase 2
Development of an Innovative Hemodialysis Method to Improve Dialytic Clearance of Protein-bound Uremic Toxins
Source: ClinicalTrials.gov · Last updated 19 Sept 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Current hemodialysis techniques fail to efficiently remove protein-bound uremic toxins (such as p-cresyl sulfate (p-CS) or indoxyl sulfate (IS)) due to their strong binding to serum albumin. The accumulation of these toxins in end-stage renal failure patients on hemodialysis is strongly suspected to contribute to the significant morbidity and mortality observed in this population. Pre-clinical studies conducted previously showed that medium-chain fatty acids (such as sodium octanoate and decanoate), which are natural ligands of albumin, can effectively displace the binding of uremic toxins on serum albumin and thus promote their elimination during a hemodialysis session. Medialipide® 20% (Braun) is an emulsion of medium chain triglycerides (MCT) (6 to 12 carbons) used in parenteral nutrition. Medialipide® constitutes a relevant clinical formulation for the administration of octanoate and decanoate because it contains 94% of sodium octanoate and decanoate. In this study, a proof of concept intervention will be carried out to study the effect on the clearance uremic toxins clearance of the perfusion of Medialipide® emulsion (as a sodium octanoate and decanoate donor) in patients during their hemodialysis session compared to a control situation Sodium chloride (NaCl) 0,9%).
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 6 Sept 2024
- Start date
- 1 Jan 2025
- Primary completion date
- 22 Jan 2027
- Lead sponsor
- Hospices Civils de Lyon
- Diseases
- Chronic kidney disease
- NCT number
- NCT06595680
- EU CT number
- 2023-510406-41-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 12
- From 1 Jan 2025 to the primary completion date, 22 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients already on Vitamin K antagonists (VKA) (or prescribed less than one month before inclusion)
- Subject participating in another interventional study involving a drug with an exclusion period still in progress at inclusion.
Other illness
- Uncontrolled hypertension \> 180/115 millimetre of mercury (mmHg)
- Patients with allergy to heparin or requiring haemodialysis without anticoagulant (recent haemorrhage)
Lab values
- Criteria relating to products/procedures: Patient with
- an allergy to egg, soya or peanut proteins or to one of the active ingredients or one of the excipients (glycerol, egg phospholipids for injection, a-tocopherol, sodium oleate (to adjust the pH), water for injection) of Médialipide
- Severe hyperlipidaemia or severe lipid metabolism disorder characterised by hypertriglyceridaemia \> 3 mmol/l
- Sepsis \< 1 month
- Severe liver failure or cholestasis
- Known severe coagulopathy
- Acute thrombo-embolic events
- Fat embolism
- Aggravating bleeding diathesis,
- Uncompensated metabolic acidosis.
- Unstable circulatory state threatening the vital prognosis (collapse and shock),
- Unstable metabolic conditions (e.g. severe post-traumatic syndrome, coma of unknown origin),
- Acute phase of myocardial infarction or stroke,
- Uncorrected disturbances of fluid and electrolyte balance, such as hypokalaemia and hypotonic dehydration.
- Decompensated heart failure,
- Acute pulmonary oedema.
Other
- Residual diuresis \> 100 mL per day
- Pregnant or breast-feeding
- Perdialytic hypotension requiring vascular filling \> 100 mL during the last 3 sessions
- Patients already on parenteral nutrition
Who the study is looking for
- Age ≥18 years
- On haemodialysis at a frequency of 3 sessions of 4 hours per week, for at least 3 months.
- For patients of childbearing age, effective contraception (sexual abstinence, hormonal contraception, intrauterine device or hormone-releasing system, cap, diaphragm or sponge with spermicide, condom) for the entire duration of treatment is required. A blood pregnancy test (beta-human chorionic gonadotropin (HCG)) will be carried out at inclusion.
- Patient affiliated to a social security scheme
- Free, informed and written consent signed by the patient
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital Edouard Herriot Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.