NCT06596369RecruitingPhase 2/3
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
Transcutaneous Spinal Cord Stimulation to Facilitate Recovery of Upper Extremity Function in Individuals With Stroke or Spinal Cord Injury - A Pilot Study
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI). More recently, the use of invasive, epidural electrical stimulation of the spinal cord has also demonstrated promise in restoring upper extremity function post-stroke. However, the effect of stimulation parameters such as electrode configuration and stimulation frequency on excitability of the nervous system remains unknown preventing the opportunity to fully exploit this noninvasive stimulation paradigm. Additionally, the utility of noninvasive tcES in the stroke population remains unexplored. This project utilizes a comprehensive set of neurophysiological techniques, in combination with carefully chosen motor tasks, to directly link and assess the effects of stimulation parameters on neural excitability and upper extremity function during and following the delivery of cervical tcES in individuals with SCI and stroke. The fundamental knowledge gained from this project will ultimately improve the implementation of this novel and non-invasive neuromodulatory tool through an improved understanding of how tcES can facilitate recovery of function.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 6 Jun 2024
- Start date
- 15 Jun 2024
- Primary completion date
- 14 Sept 2029
- Lead sponsor
- University of Alberta
- Diseases
- Stroke
- NCT number
- NCT06596369
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 30
- From 15 Jun 2024 to the primary completion date, 14 Sept 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- participants with active or inactive implants including cardiac pacemakers, implantable defibrillators, ocular implants, deep brain stimulators, vagus nerve stimulator, and implanted medication pumps
- participants with a history of seizures or epilepsy
- participants taking any medication which may reduce seizure threshold
Other
- pregnant women
- aphasia or dysphasia
- spasticity grade Modified Ashworth Scale ≥ 3
- Transcranial magnetic stimulation-specific exclusion criteria (both cohorts)
- participants with conductive, ferromagnetic or other magnetic-sensitive metals implanted in their head
Who the study is looking for
- SCI cohort:
- individuals aged 18 to 75 years of age who have suffered a spinal cord injury
- cervical level injury (C3 to C8)
- at least 1-year post-injury
- for individuals taking medications for spasmolysis or muscle relaxation (e.g. oral baclofen, tizanidine, dantrolene, vigabatrin, gabapentin, or benzodiazepine), dose and regimen must be stable for at least 4 weeks prior to screening
- Stroke cohort:
- individuals aged 18-75 years of age who have suffered any type of stroke resulting in upper extremity motor dysfunction with partially preserved motor function
- ≥ 6 months post-stroke
- At least 4 months since last BoNT injection for treatment of spasticity or any other condition or ≤ 2 months after study completion
- for individuals taking medications for spasmolysis or muscle relaxation (e.g. oral baclofen, tizanidine, dantrolene, vigabatrin, gabapentin, or benzodiazepine), dose and regimen must be stable for at least 4 weeks prior to screening
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Glenrose Rehabilitation Hospital Coordinator of this site? Confirm its status | Edmonton | Canada | Recruiting |
| University of Alberta Coordinator of this site? Confirm its status | Edmonton | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.