A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

Prior treatment

• Have received anti-interleukin (IL)-23p19 or anti-IL-12p40 antibodies in the past.
• Have experienced a thrombotic event within 24 weeks before baseline.
• Have had certain abdominal surgeries within the past 3 months or are likely to require surgery for UC during the study.

Other illness

• Have a current diagnosis of Crohn's Disease or certain other inflammatory gastrointestinal diseases.
• Have a history of certain adenomas, dysplasia's, or malignancies.

• Have had an established diagnosis of UC of ≥3 months in duration before baseline.
• Have moderately to severely active UC as assessed by the UC disease activity score.
• Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators).
• Are on a stable dose of certain oral UC medications (including corticosteroids).
• Must meet contraception requirements.