NCT06599905Completed
Pain Control in Episodic and Chronic Migraine
Endogenous Pain Control Mechanisms Throughout the Migraine Cycle and in Chronic Migraine
Source: ClinicalTrials.gov · Last updated 19 Sept 2024
Brief summary (registry, in English)
The phenomenon of offset analgesia (OA) refers to a disproportionately large decrease in perceived pain following a slight reduction in the intensity of a noxious heat stimulus. This phenomenon is considered as an indicator of the activation of the endogenous pain modulation system, whose dysfunction is implicated in the pathophysiology of migraine and other chronic pain conditions. This study aims to investigate pain processing mechanisms using the OA paradigm in individuals with episodic migraine (EM) during different phases of the migraine cycle and in those with chronic migraine (CM), with and without medication overuse headache (CMwoMOH and CM-MOH, respectively). A population of healthy subjects matched by sex and age will also be enrolled
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 90 (actual)
- First submitted
- 11 Jul 2024
- Start date
- 15 Jun 2021
- Primary completion date
- 15 Jan 2024
- Lead sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
- Diseases
- Migraine
- NCT number
- NCT06599905
What you commit to
- Study type: Interventional
- Participants enrolled: 90
- From 15 Jun 2021 to the primary completion date, 15 Jan 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- alcohol consumption or intense exercise within 24 hours prior to examination
- Use of migraine prophylactic medication for patients with EM.
Other illness
- other acute or chronic pain conditions
- serious internal, psychiatric, or neurological systemic diseases
Other
- any other headache diagnosis according to the IHS classification
- pregnancy, breastfeeding, skin pathologies in the tested trigeminal nerve area (V1)
- poor sleep quality the night before testing
- women were not assessed during their menstrual cycle.
Who the study is looking for
- patients affected by episodic or chronic migraine according to the International Headache Society (IHS) Classification (3rd edition), aged 18 to 70 years
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinical Trial Center Coordinator of this site? Confirm its status | Pavia | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.