NCT06601465RecruitingPhase 2
COgnitioN With VERiciGuat Evaluation in Heart Failure
CONVERGE-HF: COgnitioN With VERiciGuat Evaluation in Heart Failure
Source: ClinicalTrials.gov · Last updated 25 Aug 2026
Brief summary (registry, in English)
CONVERGE-HF is a 4-center pilot phase IIb randomized control trial in ambulatory patients with chronic heart failure (≥ 6 months) and mild-to-moderate cognitive impairment.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 6 Sept 2024
- Start date
- 3 Jun 2025
- Primary completion date
- 16 Jul 2028
- Lead sponsor
- University of Alberta
- Diseases
- Heart failure
- NCT number
- NCT06601465
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 120
- From 3 Jun 2025 to the primary completion date, 16 Jul 2028
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have contraindications for sGC stimulator and vericiguat therapy (i.e. use of long-acting nitrates, other soluble guanylate cyclase stimulators (e.g., riociguat), or phosphodiesterase type 5 (PDE-5), pregnancy or breast-feeding)
- General medical conditions: uncontrolled thyroid disorders, hepatic failure, or myocardial revascularization procedures \[coronary angioplasty and/or surgical revascularization in the previous 3 months\], cancer/malignancy, or with severe dementia).
Other illness
- CMR exclusions: incompatible implantable cardiac device (ICD or CRT), uncontrolled atrial fibrillation or recurrent ventricular arrhythmias).
- Patients with allergies to the study products.
Other
- Unable to undergo CMR imaging or brain MRI.
- Patients currently hospitalized.
Who the study is looking for
- Adult patients
- Established chronic heart failure (≥ 6 months)
- Mild-to-moderate cognitive impairment (as per the diagnosis of cognitive impairment or a Montreal Cognitive Assessment (MoCA) score 10-25).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Of Calgary Coordinator of this site? Confirm its status | Calgary | Canada | Recruiting |
| University of Alberta Coordinator of this site? Confirm its status | Edmonton | Canada | Recruiting |
| McGill University Health Center Coordinator of this site? Confirm its status | Montreal | Canada | Not yet recruiting |
| University of Ottawa Coordinator of this site? Confirm its status | Ottawa | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.