NCT06601491Active, not recruiting
Early Vascular Ageing Among Cypriots
Lifestyle Randomised Intervention for Healthy Vascular Ageing - a Multifactorial Assessment of Vascular Ageing Among Cypriots in Early Adulthood Through Biobank.cy
Source: ClinicalTrials.gov · Last updated 19 Sept 2024
Brief summary (registry, in English)
The LifeEVA project aims to tackle the significant public health challenge of cardiovascular disease (CVD) by addressing early vascular ageing (EVA), characterized by increased arterial stiffness and reduced vascular compliance, particularly in young adults. The project seeks to develop and implement innovative, personalized lifestyle interventions targeting Cypriots aged 18-40 who are overweight or obese. Utilizing genetic data from biobank.cy, LifeEVA aims to understand the progression of EVA and reduce CVD risk through tailored dietary and physical activity counseling. The methodology involves a prospective, randomized, open-label, blinded endpoint trial over one year. Participants will be recruited from biobank.cy's database, ensuring a robust sample. They will receive personalized interventions based on their genetic profile, including a hypocaloric diet, physical activity plan and taking into account other factors (i.e. sleep, anxiety etc). The project's work is divided into five work packages: project management, dissemination and exploitation activities, baseline assessment and recruitment, intervention implementation and data collection, and data analysis and manuscript preparation. Anticipated results include significant reductions in vascular stiffness, improved cardiovascular health markers, and enhanced understanding of the interplay between genetics and lifestyle in EVA. The project's impact extends to the establishment of a vascular health assessment clinic, contributions to public health by reducing CVD prevalence, and advancing the field of personalized preventive healthcare. LifeEVA is positioned to make significant contributions to cardiovascular research, promote innovation, and enhance the scientific and public health landscape in Cyprus.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 352 (estimated)
- First submitted
- 8 Aug 2024
- Start date
- 8 Aug 2024
- Primary completion date
- Jan 2029
- Lead sponsor
- University of Cyprus
- Diseases
- Obesity
- NCT number
- NCT06601491
What you commit to
- Study type: Interventional
- Planned participants: 352
- From 8 Aug 2024 to the primary completion date, Jan 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals currently on medication or diets that significantly affect metabolism or body weight.
- Taking any vasoactive medications.
Other illness
- Individuals with a history of eating disorders.
- Those with significant chronic diseases like advanced cardiovascular diseases
Other
- Pregnant or breastfeeding women or women to intend/are in the process of trying to get pregnant within 1-year after intervention onset.
- Those who have participated in another weight loss program or study within the last six months.
Who the study is looking for
- 18 - 40 years old.
- BMI≥25 kg/m².
- WC≥0.9 m for men and ≥0.8 m for women
Age in the registry: 18 years to 40 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| biobank.cy Center of Excellence in Biobanking and Biomedical Research, University of Cyprus Coordinator of this site? Confirm its status | Nicosia | Cyprus | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.