NCT06615232Recruiting
The Impact of Vaginal Washing on Cervical Inflammation
The Impact of Vaginal Washing on Cervical Inflammation: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
Vaginal washing is a common practice that many women perceive as hygienic. However, vaginal washing has been linked to adverse reproductive health outcomes including increased HIV acquisition risk. The mechanism linking vaginal washing to HIV risk remains unknown, but may be related to increased inflammation caused by intravaginal washing practices. The primary objective of this study is to test the hypothesis that a vaginal washing cessation intervention will reduce concentrations of soluble inflammatory mediators in cervicovaginal fluid and total immune cells in mucosal tissue, reduce cervical epithelial disruption, and increase concentrations of protective vaginal Lactobacillus spp. compared to control.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 122 (estimated)
- First submitted
- 23 Sept 2024
- Start date
- 16 May 2025
- Primary completion date
- Oct 2026
- Lead sponsor
- University of Washington
- NCT number
- NCT06615232
What you commit to
- Study type: Interventional
- Planned participants: 122
- From 16 May 2025 to the primary completion date, Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of bleeding disorder
Other
- \<3 months postpartum or current breastfeeding
- Current menstruation (can enroll after menses)
- Visible cervical abnormality requiring evaluation
- Medical contraindication to study protocol
- Visible cervicovaginal ulcers or lesions
- Positive test for gonorrhea, chlamydia, trichomonas, or wet preparation and examination findings indicating vulvovaginal candidiasis
Who the study is looking for
- Reports vaginal washing beyond the introitus in the past week
- Female, aged 18-50
- Presence of a cervix
- Informed consent obtained and form signed
- HIV-seronegative
- Non-pregnant (urine β-hCG negative)
- Willing to abstain from sex for 14 days after biopsy
- Post-menarche and pre-menopause
Age in the registry: 18 years to 50 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pwani Research Center Coordinator of this site? Confirm its status | Mombasa | Kenya | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.