NCT06618157Enrolling by invitation
Connectomic Guided DBS for Parkinson's Disease
Connectomic Guided Deep Brain Stimulation (DBS) for Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
The objective of this research is to use advanced connectomic imaging models to identify disease-relevant axonal pathway targets for better tremor control in Parkinson's disease patients while avoiding undesirable side effects, with the goal of increasing precision and facilitating the choice of optimal DBS parameters for certain disease phenotypes. The investigators hypothesize that patient centered subthalamic nucleus deep brain stimulation of cerebellothalamic axonal pathways and pallidothalamic tract activation can provide better tremor control while avoiding worsening dyskinesias in patients with Parkinson's disease with significant tremor.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 26 Sept 2024
- Start date
- 16 Feb 2026
- Primary completion date
- 29 Dec 2026
- Lead sponsor
- Duke University
- Diseases
- Parkinson disease
- NCT number
- NCT06618157
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 16 Feb 2026 to the primary completion date, 29 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who received DBS less than three months prior to the start of the study
Other
- Not having a post-operative head CT with 1mm or smaller axial slices at least 1 week after initial lead implantation.
Who the study is looking for
- Age 18 or older
- Diagnosed with Parkinson's disease and has previously been implanted with bilateral subthalamic nucleus deep brain stimulation (DBS)
- Received DBS at least three months prior to the time of the study to allow for optimization of usual clinical care
- With at least mild tremor on a pre-operatory MDS-UPDRS clinical scale as defined by at least 2 out of 4 resting tremor grading on MDS-UPDRS on at least one extremity
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke Health Center at Morreene Road Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.