NCT06619405Recruiting
AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
AMD and Validating Rod-Meditated Dark Adaptation With Everyday Task Performance
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 24 Sept 2024
- Start date
- 15 Aug 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Duke University
- Diseases
- Macular degeneration
- NCT number
- NCT06619405
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 15 Aug 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous retinal laser or surgical therapy in the study eye(s)
- Previous retinal laser or surgical therapy in the study eye(s)
Other illness
- Any other ocular condition requiring long-term therapy or surgery during the study
- The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments.
Age
- Under 50 years of age
Other
- Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading
- Presence of dense cataracts in the study eye (s) that can affect visual function tests
- Presence of glaucoma requiring treatment during the study and/or visual field defects
- The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing
- Diagnosis of nystagmus that will interfere with testing
- High myopia -8 Diopters or more severe
Who the study is looking for
- Capable and willing to provide consent
- Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls
- At least 50 years of age
Age in the registry: 50 years to 89 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke Eye Center Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.