Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

Prior treatment

• Active use of prescription medications within 14 days of Day -1
• Active use of over-the-counter, or herbal medication within 7 days of Screening
• Other investigational products within 30 days

Other illness

• Any physical or psychological condition that prohibits study completion
• History of suicidal behavior or suicidal ideation
• HIV, hepatitis B and hepatitis C positive
• Cardiac arrhythmia, or clinically significant abnormal ECG
• Any physical or psychological condition that prohibits study participation
• Diagnosis of Crohn disease, indeterminate colitis, indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, radiation colitis, and diverticular disease associated with colitis.
• HIV, hepatitis B and hepatitis C positive
• Cardiac arrhythmia, or clinically significant abnormal ECG

Other

• Parts A and B
• Heavy use of nicotine containing products
• Blood or plasma donation within 60 days
• Pregnant or breastfeeding
  • Part C
• Positive screen for Clostridium difficile (C. Difficile) toxins
• Pregnant or breastfeeding
  • Other protocol defined inclusion/exclusion criteria apply.

• Parts A and B
• Age 18-55
• Must be in good health with no significant medical history
• Clinical laboratory values within normal range
• BMI 18-35 (inclusive)
• Contraceptive use by men or women consistent with local regulations
• Able and willing to provide written informed consent
  • Part C
• Age 18-75
• Must be in good health with no significant medical history
• UC diagnosis ≥ 3 months prior to screening
• Diagnosis of moderately to severely active UC as defined by a (MMS) ≥ 5, with a MES ≥ 2 and RBS ≥ 1
• Evidence of UC extending ≥ 15 cm from the anal verge, as determined by screening colonoscopy
• Must have inadequate response to, loss of response to, or intolerance to at least 1 of the conventional or advanced therapies of UC
• Able and willing to provide written informed consent