The Effect of Long-term Use of Bisphosphonates on Femur Morphology

Brief summary (registry, in English)

Recent studies have shown that bone modeling can occur throughout life, suggesting bone has a persistent ability of adapting structure to loading. Some bone medications have a significant effect on the process of bone modeling based on histological studies. Bisphosphonates (BP), a classical anti-resorption drug which impacts the process of bone turnover, is related with atypical femur fractures while the mechanism is unclear. Several hypotheses are considered competitive. Among them, increased femur bowing is associated with atypical femoral fractures. However, it remains doubtful whether long-term BP use increases femur bowing. Thus, the investigators design this retrospective cohort study.

What you commit to

• Study type: Observational
• Participants enrolled: 140
• From 1 Jun 2024 to the primary completion date, 1 Jul 2024
• 1 site in 1 country
• Visits and tests: ask the trial team, the registry does not list them

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Who the study is looking for

Sex: All · Accepts healthy volunteers

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Sites (1)

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