NCT06621602Active, not recruiting
Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
This study aims to assess the levels of phosphorylated alpha-synuclein (P-SYN) in patients with Parkinson's disease and REM Behavior Disorder using a minimally invasive skin punch biopsy. It seeks to understand the natural progression of P-SYN deposition over time to explore the potential of P-SYN quantification as a biomarker for disease progression.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 23 Sept 2024
- Start date
- 17 Dec 2024
- Primary completion date
- Apr 2027
- Lead sponsor
- CND Life Sciences
- Diseases
- Parkinson disease
- NCT number
- NCT06621602
What you commit to
- Study type: Observational
- Planned participants: 100
- From 17 Dec 2024 to the primary completion date, Apr 2027
- 18 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Clinical evidence of severe vascular disease (history of ulceration, poor wound healing or vascular claudication)
- History of allergic reaction to Lidocaine for local anesthesia needed for skin biopsies
- Significantly impaired wound healing or history of scarring or keloid formation
Other
- Use of blood thinners (Plavix or Aspirin used separately is allowed)
Who the study is looking for
- Male and female 50 to 85 years of age
- Clinical confirmed diagnosis of Parkinson's disease or REM Sleep Behavior
Age in the registry: 50 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atlanta NeuroScience Institute ANI Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| University of Colorado Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Aventura Neurologic Associates, LLC Coordinator of this site? Confirm its status | Aventura | United States | Unknown status |
| Parkinson's Disease and Movement Disorders Center - Boca Raton Coordinator of this site? Confirm its status | Boca Raton | United States | Unknown status |
| Boston Neuro Research Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| The Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Parkinson's Research Centers of America - Long Island Coordinator of this site? Confirm its status | Commack | United States | Unknown status |
| Parkinson's Research Centers of America - Orange County Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| Parkinson's Disease and Movement Disorders Center at KUMC Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Cedars Sinai Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Neurology Multidisciplinary Clinic at Norton Healthcare Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Veracity Neuroscience LLC Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Medstar Montgomery Medical Center Coordinator of this site? Confirm its status | Olney | United States | Unknown status |
| Parkinson?s Research Centers of America ? Palo Alto Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| UT Health San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Movement Disorders Center of Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| CND Life Sciences Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
Related publications
- The Syn-Q study: detection of cutaneous phosphorylated alpha-synuclein in Parkinson's disease progression: a trial protocol.Front Neurol · 2026 · PMID 42057930
This page is information, not medical advice. Discuss any trial with your doctor.