NCT06624137Terminated
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Computationally, Electrophysiologically, and Qualitatively Characterizing Serotonergic Psychedelics; Transdiagnostic Therapeutic and Pro-Psychotic Effects
Source: ClinicalTrials.gov · Last updated 9 Jul 2026
Reason given: Funding ended.
Brief summary (registry, in English)
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic psychedelic. The goal of this observational study is to learn how the brain's information processing changes during and following administration of serotonergic psychedelics (psilocybin, N,N-Dimethyltryptamine/DMT, Lystergic Acid Diethylamide/LSD, etc.) for people with and without mental illness receiving serotonergic psychedelics through any clinical trial at Yale University. The main questions it aims to answer are: 1. Do serotonergic psychedelics cause the brain to rely on new information more than previously learned information while under the influence? What about 1 day, 5-14 days, and 4-6 weeks after use? 2. Do serotonergic psychedelics cause long-lasting side-effects in how people perceive (see, hear, feel, etc.) the world and how easily people change their beliefs? 3. How does the brain's electrical activity change after using serotonergic psychedelics? How does the balance between excitation and inhibition change while under their effect? 4. Can changes in how the brain uses information predict who will benefit from a psychedelic and who will have side effects from psychedelics? Researchers will compare with people given placebos to see what changes in brain processing are unique to serotonergic psychedelics. Participants will have the opportunity to do some combination of the following: 1. Online computer assessments consisting of games and questionnaires that probe how participants think. 2. Magnetoencephalography (MEG) or electroencephalography (EEG) with eyes closed and with repeated clicks, images, or sensations delivered. 3. A magnetic resonance imaging (MRI) scan. 4. Semi-structured qualitative interviews about their experience after taking a serotonergic psychedelic recorded via Zoom.
- Status (registry)
- Terminated
- Study type
- Observational
- Enrollment
- 5 (actual)
- First submitted
- 30 Sept 2024
- Start date
- 12 Dec 2024
- Primary completion date
- 14 Jun 2026
- Lead sponsor
- Yale University
- Diseases
- Depression, Migraine
- NCT number
- NCT06624137
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of seizures based on self-report
- Contraindications for MR scanning including metallic implants of any kind, pacemakers and history of accidents with metal, claustrophobia (specific to those who will participate in MRI)
Other
- Current intoxication based on self-report
- Any neurological, medical or developmental problem that is known to impair cognition significantly based on self-report
Who the study is looking for
- Participation in approved clinical protocol at Yale University involving potential administration of serotonergic psychedelics
- Absence of pre-existing psychotic symptoms
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Connecticut Mental Health Center | Hamden | United States | Unknown status |
| West Haven VA Medical Center | West Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.