NCT06626724Completed
A Retrospective Cohort Study on Predicting Delayed Graft Function in Liver Transplant Patients with Hepatocellular Carcinoma: a Nomogram and Machine Learning Approaches.
Source: ClinicalTrials.gov · Last updated 4 Oct 2024
Brief summary (registry, in English)
Background: This study aimed to develop a predictive model for delayed graft function (DGF) in liver transplant patients with hepatocellular carcinoma (HCC) based on preoperative biochemical indicators, using both logistic regression and XGBoost machine learning algorithms. Methods: A retrospective cohort study was conducted, including 131 liver transplant patients from January 2020 to April 2022. Preoperative biochemical markers and hematological parameters were analyzed. Logistic regression and XGBoost models were constructed to predict DGF, and their performance was evaluated using the area under the ROC curve (AUC). Shapley Additive Explanations (SHAP) analysis was employed to interpret the feature contributions.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 131 (actual)
- First submitted
- 1 Oct 2024
- Start date
- 1 Jan 2020
- Primary completion date
- 30 Apr 2024
- Lead sponsor
- Jian You
- NCT number
- NCT06626724
What you commit to
- Study type: Observational
- Participants enrolled: 131
- From 1 Jan 2020 to the primary completion date, 30 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Serious complications associated with liver transplantation, such as acute transplant rejection or transplant liver failure, occur within 7 days after surgery.
- Re-surgery within 7 days after surgery due to liver transplant-related complications or other surgical procedures, such as transplant site infection or other major surgery.
Age
- Recipients were younger than 18 years and older than 75 years
Other
- Primary non-hepatocellular carcinoma
- Due to incomplete or missing clinical data, this dataset did not meet the criteria for inclusion in the statistical analysis.
Who the study is looking for
- Patients with liver cancer aged between 18 and 75 years.
- Patients who have received liver transplantation.
- Complete preoperative and postoperative medical imaging data, clinical records and pathological test reports are available.
Age in the registry: 18 days to 75 days · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongnan Hospital of Wuhan University Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.