NCT06627192Not yet recruiting
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-α Levels in GCF
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-a Levels in Gingival Crevicular Fluid (Case Control Study)
Source: ClinicalTrials.gov · Last updated 30 Jan 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
There is a strong crossway relationship between periodontitis and hypertension. Hypertension is the most prevalent of cardiovascular diseases and its prevalence is increased by the presence of periodontitis. Periodontal attachment loss is higher in hypertension patients when compared to healthy subjects. Both are examples of non-communicable diseases (NCDs), also known as chronic inflammatory diseases, they tend to be of long duration and are the result of a combination of genetic, physiological and environmental factors. The lack of an appropriate balance between these factors results in cellular changes as well as the levels of cytokines with subsequent changes in clinical manifestations of periodontal diseases. Both periodontitis and hypertension are associated with inflammation and an increase in specific proinflammatory cytokines. Aim of the study: To investigate the correlation between the clinical parameters and the levels of Endocan and TNF-α in gingival crevicular fluid (GCF) before and after non-surgical periodontal therapy (NSPT) in stage II periodontitis patients with hypertension in comparison to non-hypertensive patients.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 26 Aug 2024
- Start date
- 10 Mar 2025
- Primary completion date
- 30 Oct 2025
- Lead sponsor
- Ain Shams University
- Diseases
- High blood pressure
- NCT number
- NCT06627192
What you commit to
- Study type: Observational
- Planned participants: 40
- From 10 Mar 2025 to the primary completion date, 30 Oct 2025
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients taking antibiotic, anti-inflammatory, and immunosuppressive therapy during the preceding 3 months before the start of the trial and during the study.
- Patients who have undergone any periodontal therapy in the last 6 months.
Other illness
- Patients with other systemic diseases, such as diabetes mellitus, rheumatoid arthritis and cancer.
- (According to Cornell Medical Index-Health Questionnaire).
Other
- Smokers.
- Pregnant and lactating females.
Who the study is looking for
- Patients with stage II periodontitis and controlled hypertension (self-reported history of a diagnosis of HTN by a physician and blood pressure (SBP \< 140 and DBP \< 90).
- Both genders aged from 30-70.
- Minimum 20 natural teeth excluding third molars.
- Good compliance with the plaque control instructions following initial therapy.
- Availability for follow-up and maintenance program.
Age in the registry: 30 years to 70 years · Sex: All
This page is information, not medical advice. Discuss any trial with your doctor.