NCT06634004Enrolling by invitation
Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya
Personalized Hemodynamic and Metabolic Signatures of Revascularization Response in Moyamoya Disease
Source: ClinicalTrials.gov · Last updated 14 Jan 2026
Brief summary (registry, in English)
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD). MMD is a condition characterized by narrowing or obstruction of major arteries in the brain and people with MMD have a high risk of stroke. Study participants will be enrolled from Vanderbilt University Medical Center and Johns Hopkins Hospital and will undergo up to two MRI scans where measurements of cerebrovascular reserve are performed using inhaled room air mixed with 5% carbon dioxide. Scans will be performed before and after surgeries to treat MMD, all surgeries are clinically indicated and are not research procedures. To further understand how surgeries impact brain health, we will also perform neurological exams and cognitive testing at approximately the same time as the imaging scans. The overall goal is to incorporate advanced imaging and cognitive assessments to understand how surgeries improve brain health in these patients, and furthermore, to use this information to develop improved screening tools for stroke risk and decisions about surgery.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 30 Sept 2024
- Start date
- 11 Sept 2023
- Primary completion date
- 11 Sept 2029
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Stroke
- NCT number
- NCT06634004
What you commit to
- Study type: Observational
- Planned participants: 100
- From 11 Sept 2023 to the primary completion date, 11 Sept 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of other major neurological conditions (including but not limited to Parkinson\'s disease, Alzheimer\'s disease, and Multiple Sclerosis) as confirmed by neuroimaging and neurological evaluation (central adjudication committee).
- History of traumatic brain injury
- Independent medical condition expected to lead to death within two years.
- Condition associated with syndromic moyamoya (including but not limited to sickle cell disease, atherosclerosis, neurofibromatosis, Down syndrome).
- Severe respiratory illness including but not limited to asthma or chronic obstructive pulmonary disease.
- 7\. Contraindication to 3 Tesla MRI 8. Pregnancy
Other
- -Both moyamoya and healthy controls
Who the study is looking for
- Moyamoya
- Clinical diagnosis of moyamoya disease as defined by gold-standard catheter angiography and consensus adjudication of imaging and neurological findings
- Age = 18-60 years
- Participants for the surgical revascularization aims must be scheduled for clinically indicated indirect surgical revascularization of at least one hemisphere
- Speak and read English
- Healthy controls
- No major medical conditions
- Age = 18-60 years
- Speak and read English
- Able to complete 2 study MRIs and all other study procedures
Age in the registry: 18 years to 69 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.