NCT06635252Completed
Statins, Cholesterol and Cognitive Decline in Alzheimer's
Source: ClinicalTrials.gov · Last updated 2 May 2025
Brief summary (registry, in English)
Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer's disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms. The investigators aim to estimate the causal effect of statins on cognitive function measured by MMSE and to identify the mediating or modifying effect of cholesterol between statins and cognitive function in patients with Alzheimer's disease.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 2000 (actual)
- First submitted
- 8 Oct 2024
- Start date
- 1 Jan 2025
- Primary completion date
- 1 Mar 2025
- Lead sponsor
- Karolinska Institutet
- Diseases
- Alzheimer disease
- NCT number
- NCT06635252
What you commit to
- Study type: Observational
- Participants enrolled: 2000
- From 1 Jan 2025 to the primary completion date, 1 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with at least one measurement of low-density lipoprotein cholesterol (LDL-C) within 1 year before dementia diagnosis.
Other
- All patients with a missing MMSE score at diagnosis date will be excluded from the analyses.
Who the study is looking for
- All patients with AD and mixed dementia registered in SveDem and from SCREAM.
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Karolinska Institutet Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.