NCT06636565Completed
Comparison of Pulmonary Function, Exercise Capacity, and Physical Activity Level Between Children With Hemophilia and Healthy Controls
Source: ClinicalTrials.gov · Last updated 10 Sept 2025
Brief summary (registry, in English)
Hemophilia is a rare X-linked congenital bleeding disorder characterized by deficiency of clotting factor VIII (hemophilia A) or deficiency of factor IX (hemophilia B) with complex diagnosis and management. Participation in physical activity is still limited in children with hemophilia, probably due to protective attitudes of families/patients and avoidance of activity, and possibly also as a result of chronic pain. Exercise capacity has been identified as a protective factor against joint problems in hemophilia. Aerobic fitness is associated with better pulmonary function in children. Chronic pain and decreased range of motion due to recurrent bleeding in joints and muscles in hemophilia may indirectly affect posture and respiratory mechanics, leading to impaired pulmonary function. This study aims to compare pulmonary function, exercise capacity, posture, and physical activity level between children with hemophilia and healthy controls and to investigate the relationship between these parameters.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 34 (actual)
- First submitted
- 7 Oct 2024
- Start date
- 25 Jul 2024
- Primary completion date
- 25 Jul 2025
- Lead sponsor
- Hacettepe University
- Diseases
- Haemophilia
- NCT number
- NCT06636565
What you commit to
- Study type: Observational
- Participants enrolled: 34
- From 25 Jul 2024 to the primary completion date, 25 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Being inhibitor positive at the time of enrollment,
Other illness
- Having a history of acute joint bleeding,
- Having a history of acute intramuscular bleeding,
- Having a history of surgery on any of the lower extremity joints,
- Having a history of injury or surgery in any of the lower extremity joints
Other
- Being unable to bear weight on the extremities,
- Having undergone radionuclide synovectomy,
- Having a severe cardiovascular, orthopedic or neurological problem that may affect the assessments.
- Control group
- Having any problem that may affect the tests
- Not having full range of motion in the upper extremity
- Having a neurological deficit
- Having pain or movement limitation in the lower extremity
Who the study is looking for
- Having been diagnosed with hemophilia and being clinically stable,
- Being between the ages of 8-18,
- Being on prophylaxis treatment (a routine treatment),
- Being 125 cm or taller,
- Being inhibitor negative at the time of enrollment,
- To be able to cooperate with the tests to be performed,
- Being willing to participate in the study.
- Not having any known internal or chronic disease
- Being male between the ages of 8-18
- Having full range of motion in the upper extremity
- Having full range of motion in the lower extremity
- Not having any history of injury or surgery in the lower extremity
- Being 125 cm or taller
- Being willing to participate in the study
Criteria the registry did not label
- Hemophilia group
Age in the registry: 8 years to 18 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hacettepe University Faculty of Physical Therapy and Rehabilitation Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.