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NCT06638125Not yet recruitingPhase 1/2

3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial

Source: ClinicalTrials.gov · Last updated 2 Feb 2026

Brief summary (registry, in English)

With the advent of CT screening for lung cancer, an increasing number of NSCLCs are being detected at very early stages, and the demand for pulmonary segmentectomy is rising rapidly. As such, there is a need to develop new surgical techniques to facilitate minimally invasive pulmonary segmentectomy, as segmentectomy may provide a number of significant advantages over lobectomy for patients presenting with early-stage lung cancer, or for patients unable to undergo a full lobectomy due to existing comorbidities. This study will provide the first case series using preoperative 3D virtual reality (VR) anatomical planning (Elucis) added to ICG and NIF-guided robotic segmentectomy to date and will be the first reported use of Elucis-guided targeted pulmonary segmental resection in Canada. As lung cancer is the most frequently fatal cancer in North America, many thousands of patients will be able to benefit from this operation every year. If successful, this project will establish a novel operation that has the potential of increasing the rates of success for segmental resection. This will allow for further research that will externally validate this technique and ensure that it is reproducible in other centres by other surgeons. As segmental resection is the new standard of care for surgical management of early-stage NSCLC, and because lung cancer is the most frequently fatal cancer in North America, many thousands of patients will be able to benefit from this operation every year. Equally importantly, the investigators believe that this method will enable them to develop a new way of teaching lung resections, in a manner that is more effective for learners. Further research on the role of VR in teaching lung cancer surgery will very likely be a downstream effect of developing this surgical method.

Status (registry)
Not yet recruiting
Phase (registry)
Phase 1/2
Study type
Interventional
Enrollment
89 (estimated)
First submitted
3 Oct 2024
Start date
1 Dec 2026
Primary completion date
30 Nov 2028
Lead sponsor
St. Joseph's Healthcare Hamilton
Diseases
Lung cancer
NCT number
NCT06638125

What you commit to

  • Study type: Interventional · Phase 1/2
  • Planned participants: 89
  • From 1 Dec 2026 to the primary completion date, 30 Nov 2028
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Women who are currently pregnant or breastfeeding; or women of childbearing potential who are not currently taking adequate birth control.

Lab values

  • Hypersensitivity or allergy to ICG, sodium iodide, or iodine

Who the study is looking for

  • Age \>/= 18 years
  • Tumour size \< 3 cm
  • Clinical Stage 1 Non-Small Cell Lung Cancer (NSCLC)
  • CT-imaging confirming that the tumour is confined to one broncho-pulmonary segment, rendering the patient a candidate for segmental resection.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
St. Joseph's Healthcare Hamilton
Coordinator of this site? Confirm its status
HamiltonCanadaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.