NCT06641726Recruiting
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
Developing an Internationally-diverse, Linked Genomic and Longitudinal Phenotypic Research Dataset to Accelerate Precision Psychiatry for Patients With Serious Mental Illness
Source: ClinicalTrials.gov · Last updated 3 Oct 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved treatments. The investigators will achieve aims by gathering information and biological samples from over 50,000 research participants and then linking this information with participants' electronic health records, genetic and other potential markers of mental illnesses (called biomarkers, derived from biological samples). The investigators will use this resource to analyse how potential risk factors - genetic, other biological and non-biological (related to the participants' life circumstances) - influence participants' experiences, symptoms, and outcomes (both mental and physical health). The investigators will also use advanced analysis to assess whether there may be better ways of grouping together and understanding the experiences of those with severe mental illnesses and dementias. Given the value and importance of this resource for advancing mental health research, the investigators will also make the data available to other researchers to pursue these broad research aims.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50000 (estimated)
- First submitted
- 8 Oct 2024
- Start date
- 16 May 2025
- Primary completion date
- 1 Jan 2035
- Lead sponsor
- Akrivia Health
- Diseases
- Schizophrenia, Bipolar disorder
- NCT number
- NCT06641726
What you commit to
- Study type: Observational
- Planned participants: 50000
- From 16 May 2025 to the primary completion date, 1 Jan 2035
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients diagnosed with depression (only an exclusion criterion for MCI/SCI patients), psychosis, bipolar disorder prior in the pre-index period - to be checked at screening.
Other illness
- Patients without capacity to provide consent. Dementia cohort
- Patients with dementia in Creutzfeldt-Jakob disease (CJD), Huntington's, HIV dementia, alcohol-related dementia, intellectual disability, traumatic brain injury at any time.
Other
- \- Mental Health cohort(s)
- Inability to understand spoken and/or written spoken English
- Individuals with intellectual disability.
Who the study is looking for
- \- All participants must have an electronic health record in a primary or secondary care service.
- Mental Health cohort(s) • Have received a diagnosis and/or treatment/referral for mental illness for MDD, BD, Schizophrenia.
- Having an available electronic health record
- Current age 18+ (no upper age limit)
- Can speak English Dementia cohort
- Participants aged 18+ (no upper age limit)
- Currently alive and are, or have been, old age psychiatry patients
- •
- Received relevant diagnosis or referral:
- EITHER
- Clinical diagnosis of dementia, mild cognitive impairment (MCI) or subjective cognitive impairment (SCI) OR
- Memory clinic referral
- Must be willing and able to complete a validated cognitive assessment (MoCA or SLUMS).
- All dementia patients will undergo the extended biomarker analysis.
Age in the registry: 18 years to 110 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| GlobalMinds central study team Coordinator of this site? Confirm its status | Oxford | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.