A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight

Prior treatment

• Have a prior or planned surgical treatment for obesity
• Have Type 1 Diabetes, latent autoimmune diabetes, been diagnosed with any form of diabetes mellitus except for a prior diagnosis of gestational diabetes mellitus, or history of ketoacidosis or hyperosmolar coma
• Have any of the following cardiovascular conditions within 3 months prior to screening:
  • acute myocardial infarction
  • cerebrovascular accident (stroke)
  • unstable angina, or
  • hospitalization due to congestive heart failure
• Currently taking or have taken medications that may cause significant weight gain or promote weight loss within 3 months prior to screening

Other illness

• Have poorly controlled hypertension
• Have ongoing or a history of frequent intermittent or chronic tachyarrhythmia syndromes
• Have ongoing or a history of bradyarrhythmias other than sinus bradycardia
• Have a history of New York Heart Association (NYHA) Functional Classification III or IV congestive heart failure
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have signs and symptoms of any liver disease
• Have a disease or condition known to cause gastrointestinal malabsorption or a known clinically significant gastric emptying abnormality
• Have a history of acute or chronic pancreatitis
• Have renal impairment, measured as estimated glomerular filtration rate \<30 mL/minute/1.73 m2

Lab values

• Have at least one laboratory value suggestive of diabetes during screening
• Use of metformin, or any other glucose-lowering medications

• Have a BMI of
  • ≥30 kilograms per square meter (kg/m2) or
  • ≥27 kg/m2 and \<30 kg/m2, with at least one of the following weight-related comorbidities:
  • Hypertension
  • Dyslipidemia
  • Cardiovascular disease
  • Obstructive sleep apnea
• Have had a stable body weight for the 3 months prior to randomization (\<5% body weight gain and/or loss)