NCT06645756Completed
Comparative Analysis of Postprandial Effects in Healthy and Obese Individuals
Source: ClinicalTrials.gov · Last updated 6 Aug 2025
Brief summary (registry, in English)
After eating, blood composition changes, including increased triglycerides and glucose, which can trigger postprandial inflammation. Particularly with high-fat foods, pro-inflammatory lipopolysaccharide (LPS) increases. This activates leukocytes to release pro-inflammatory cytokines. In industrialized countries where "snacking" is common, many people spend the day in a postprandial state. Obese individuals tend to have chronic inflammation and show increased susceptibility to infections such as SARS-CoV-2. The main objective of the study is to investigate the response of leukocytes and the serum metabolome after food intake in individuals with obesity compared to healthy individuals, focusing on LPS as a key stimulus of innate immunity.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 38 (actual)
- First submitted
- 21 Sept 2023
- Start date
- 13 Dec 2023
- Primary completion date
- 6 Nov 2024
- Lead sponsor
- University of Hohenheim
- Diseases
- Obesity
- NCT number
- NCT06645756
What you commit to
- Study type: Interventional
- Participants enrolled: 38
- From 13 Dec 2023 to the primary completion date, 6 Nov 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking statins or other lipid-lowering medications (e.g., ezetimibe, fibrates)
- Participation in another clinical study (current or within the last 30 days prior to study entry)
- A medical condition or regular medication use that, at the investigator's discretion, does not permit study participation or evaluation of study parameters or consumption of the investigational product (individual decision)
Other illness
- Manifest diabetes mellitus
- Acute/unstable cardiovascular diseases
- Acute inflammatory diseases
- autoimmune diseases
- kidney diseases
- food allergy or food intolerance to food components of the test meal (e.g. eggs)
- celiac disease
Other
- Nicotine consumption
- High-risk alcohol consumption (more than one standard glass per day for women, more than two standard glasses per day for men)
- Antibiotic intake
- Taking probiotics, prebiotics and synbiotics, unless taken for more than 90 days
- Taking oral antidiabetics
- Taking antacids
- Pregnancy and lactation
- Inability to consume the test meal orally
- Placement in a clinic or similar facility due to official or court order (medical history)
Who the study is looking for
- Signed declaration of consent
- from 25 years of age
- BMI 20 kg/m2 - 25 kg/m2 or BMI 30 kg/m2 - 40 kg/m2
- Good venous conditions for blood collection
- Sufficient understanding of the German language and sufficient mental state to understand information and instructions related to the study
Age in the registry: 25 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Metabolic Unit der Universität Hohenheim Coordinator of this site? Confirm its status | Stuttgart | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.