NCT06647459Terminated
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial
Source: ClinicalTrials.gov · Last updated 6 May 2026
Reason given: Grant proposal was sent to NIH 3 times but did not score well enough to receive funding
Brief summary (registry, in English)
To use programmed ventricular stimulation at the time of AF ablation to define the prevalence and mechanism of inducible ventricular tachycardia (VT); pace-mapping to define the site of origin of ventricular arrhythmias; and voltage mapping to define low voltage scar substrate in the basal LV in patients with pathogenic TTN variants compared to genotype-negative controls.
- Status (registry)
- Terminated
- Study type
- Observational
- Enrollment
- 32 (actual)
- First submitted
- 15 Oct 2024
- Start date
- 13 Dec 2023
- Primary completion date
- 28 Apr 2026
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Atrial fibrillation
- NCT number
- NCT06647459
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Diagnosed with a genetic CM or arrhythmia syndrome prior to AF
- Previous PVC or VT ablation
- Prior myocardial infarction.
Lab values
- LVEF <20%
Other
- VUS in 'possibly pathogenic' subgroup (control group only)
- Pacemaker or ICD
- Prosthetic mitral or aortic valve
- Contraindication to heparin
Who the study is looking for
- Adults aged 18 and older
- Diagnosed with AF before age 60
- Scheduled for catheter-based AF ablation (de-novo or repeat)
- Able to provide written, informed consent
- P/LP variant in TTN or other CM gene (cases) or identified as a genotype-negative control.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.