NCT06650995Recruiting
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
Source: ClinicalTrials.gov · Last updated 18 Sept 2026
Brief summary (registry, in English)
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 18 Oct 2024
- Start date
- 1 Feb 2027
- Primary completion date
- 25 Feb 2027
- Lead sponsor
- Technical University of Munich
- Diseases
- Heart failure, Atrial fibrillation
- NCT number
- NCT06650995
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Feb 2027 to the primary completion date, 25 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior ablation therapy
Other illness
- Clinically unstable coronary artery disease or acute coronary syndrome
- Precapillary pulmonary hypertension at rest
- High-degree valve insufficiency or stenosis (greater than grade 1 at rest)
Lab values
- Left ventricular ejection fraction \<50%
Other
- Paroxysmal, long-persistent or permanent atrial fibrillation
- Physical and/or mental inability to perform exercise testing
- Intracardiac shunts
Who the study is looking for
- Diagnosed heart failure with preserved ejection fraction
- Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion)
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Medicine, Division of Prevention and Sports Medicine TU Munich Coordinator of this site? Confirm its status | Munich | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.