NCT06653348RecruitingPhase 2/3
Ticagrelor Based De-Escalation of Dual Antiplatelet Therapy in Ischemic Stroke
De-Escalation of Dual Antiplatelet Therapy With Ticagrelor and Aspirin in Non-disabling Non-cardioembolic Ischemic Stroke or High Risk TIA Patients: A Randomized, Outcome Assessor Blind, Controlled Trial
Source: ClinicalTrials.gov · Last updated 27 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a randomized, controlled, outcome assessor blind, parallel group design pilot study on 100 patient with diagnosis of ischemic stroke admitted in Bou-Ali Sina Hospital, Sari,Iran.The aim of study is to compare the efficacy of 90 mg ticagrelor BID plus aspirin for 1 month and 60 mg ticagrelor BID plus aspirin for 6 months in reduce of non-disabling non-cardioembolic ischemic stroke or high risk TIA recurrence during first 12 months.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 19 Oct 2024
- Start date
- 1 Apr 2024
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Mazandaran University of Medical Sciences
- Diseases
- Stroke
- NCT number
- NCT06653348
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 100
- From 1 Apr 2024 to the primary completion date, 1 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- any indication for anticoagulant therapy
- acute phase treatment with intravenous thrombolysis or thrombectomy
- any contraindication for consumptive drug
Other illness
- history of hypersensitivity to consumptive drug
- history of intracranial hemorrhage
- history of GI bleeding during past 6 m
- history of coagulopathy
Other
- candidate for endarterectomy
- active hemorrhagic diathesis during randomization
Who the study is looking for
- signing inform consent,
- recent ischemic stroke within 24 h,
- diagnosed by brain CT or MRI mild stroke with NIHSS =\<8 and no evidence of large infarct in brain imaging
- high risk TIA with ABCD \>4,
- no cardioembolic source such as low E/F, MS, AF ,...
- no specific etiology such as dissection, vasculitis, ...
- no carotid stenosis \> 50 % in side of involvement
Age in the registry: 40 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mazandaran province, Sari,Iran Coordinator of this site? Confirm its status | Sari | Iran | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.