NCT06655623Completed
A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case
A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression - DEPRE-ST*Case
Source: ClinicalTrials.gov · Last updated 17 Apr 2026
Brief summary (registry, in English)
This clinical multiple case study seeks to expand the knowledge of how schema therapy could function as an intervention for difficult-to-treat depression. The study will explore in depth the course of a 30 session treatment with schema therapy conducted over approximately one year on three individual patients at two different psychiatric treatment sites. Together, the data from this study will inform about the feasibility of schema therapy for difficult-to-treat depression as well as form the base for recommendations in adapting schema therapy for this particular patient group.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 2 (actual)
- First submitted
- 15 Oct 2024
- Start date
- 6 Nov 2024
- Primary completion date
- 20 Feb 2026
- Lead sponsor
- Region of Southern Denmark
- Diseases
- Depression
- NCT number
- NCT06655623
What you commit to
- Study type: Interventional
- Participants enrolled: 2
- From 6 Nov 2024 to the primary completion date, 20 Feb 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Bipolar or psychotic disorder
- Known to be pregnant at time of inclusion
- Psychiatric comorbidity is not an exclusion criteria, until the comorbid disorder is understood to be the primary psychiatric problem and as such the patient would be treated in a different care package, e.g., for Post-Traumatic Stress Disorder
- (The inclusion and exclusion criteria follow that of the mother study (clinicaltrial.gov ID NCT05833087))
Other
- Alcohol or substance abuse
- Acute suicidal risk
- Mental disability (estimated IQ \< 70)
- Non-Danish speaker
Who the study is looking for
- Participants have at the time of inclusion been referred to treatment for depression as a primary diagnosis in a psychiatric clinic
- Participants should meet the diagnosis of chronic or treatment-resistant depression as follows:
- Clinical major depression as measured by the M.I.N.I. diagnostic interview: duration minimum two years OR persistent after = 2 trials of antidepressants from different classes, in an adequate dosage and time period (= 4 weeks) OR moderate treatment resistance as measured on the MSM-scale, score \> 6
- Minimum a score of 9 points on the Hamilton Rating Scale for Depression 6 (HAMD-6), corresponding to moderate to severe depression
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Psychotherapeutic Out-patient Clinic, Psychiatric Center Copenhagen/Nannasgade, Mental Health Services, Capital Region of Denmark Coordinator of this site? Confirm its status | Copenhagen | Denmark | Unknown status |
| Psychotherapeutic Clinic Frederiksberg, Psychiatric Center Copenhagen, Mental Health Services, Capital Region of Denmark Coordinator of this site? Confirm its status | Frederiksberg | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.