Safety, Tolerability, and Effectiveness of Duodenal Mucosal RF Vapor Ablation for Insulin Elimination in Type-2 Diabetes

Prior treatment

• Previous gastrointestinal surgery that could limit treatment of the duodenum such as Billroth 2, Roux-en-Y gastric bypass, or other similar procedures or conditions. (Prior laparoscopic sleeve gastrectomy (LSG) will not be an exclusion).
• Acute gastrointestinal illness in the previous 7 days.
• Current use of anticoagulation therapy (e.g. warfarin) or direct-acting oral anticoagulants (e.g. rivaroxaban, apixaban, edoxaban and dabigatran) that cannot be discontinued for 3-5 days before and 7 days after the procedure.
• Current use of P2Y12 inhibitors (clopidogrel, prasugrel, ticagrelor) that cannot be discontinued for 5 days before and 7 days after the procedure.
• Unable to discontinue non-steroidal anti-inflammatory drugs (NSAIDs) during treatment through 4 weeks following the procedure. Use of acetaminophen and low dose aspirin is allowed.
• Use of systemic glucocorticoids (excluding topical or ophthalmic application or inhaled forms) for more than 10 consecutive days within 12 weeks prior to the baseline visit.
• Use of drugs known to affect gastrointestinal motility (e.g. Metoclopramide)
• Use of weight loss medications such as Sibutramine (e.g. Meridia), Orlistat (e.g. Xenical), Phentermine or over-the-counter weight loss medications (prescription medication)
• Significant cardiovascular disease, including known history of valvular disease, or myocardial infarction, heart failure, transient ischemic attack, or stroke within 6 months prior to the Screening Visit.
• Participating in another ongoing clinical trial of an investigational drug or device.

Other illness

• Diagnosis of Type 1 diabetes mellitus
• Any history of diabetic ketoacidosis or hyperosmolar nonketotic coma
• History of severe hypoglycemia (more than 1 severe hypoglycemic event, as defined by need for third-party assistance, in the last year).
• Known autoimmune disease, including but not limited to celiac disease, duodenal Crohn disease or pre-existing symptoms of systemic lupus erythematosus, scleroderma or other systemic autoimmune connective tissue disorder.
• History of pancreatitis (acute or chronic).
• Known active hepatitis or active liver disease.
• Known history of severe irritable bowel syndrome, radiation enteritis or other inflammatory bowel disease, such as Crohn's disease.
• Known history of a structural or functional disorder of the esophagus that may impede passage of the device through the gastrointestinal tract or increase risk of esophageal damage during an endoscopic procedure, including moderate-severe (Grade C or D) esophagitis, dysphagia due to achalasia or stricture/stenosis, esophageal varices, esophageal perforation, or any other disorder of the esophagus.
• Upper gastrointestinal conditions such as active ulcers, polyps, varices, strictures, congenital or acquired duodenal telangiectasia.
• Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
• Uncontrolled thyroid disease
• Known immunocompromised status, including but not limited to individuals who have undergone organ transplantation, chemotherapy, or radiotherapy within the past 12 months, who have clinically significant leukopenia, who are positive for the human immunodeficiency virus (HIV) or whose immune status makes the participant a poor candidate for clinical trial participation in the opinion of the investigator.
• Active malignancy within the last 5 years (excluding non-melanoma skin cancers)
• Active systemic infection
• Any other mental or physical condition which, in the opinion of the study investigator, makes the participant a poor candidate for clinical trial participation.
• Use of heart pacemaker or other electronic device implants

Lab values

• Persistent anaemia, defined as haemoglobin ≤ 9 g/dL
• Estimated glomerular filtration rate (eGFR) ≤ 45 ml/min/1.73m2 (estimated by MDRD).

Age

• Critically ill or has a life expectancy \< 3 years.

Other

• Current use of insulin pump.
• Current, or within the last 3 months, use of a GLP-1 analogue.
• Current use of a long-acting sulphonylureas (e.g. glibenclamide, chlorpropamide, glimepiride, glyburide)
• Known diabetic gastroparesis.
• Mean of 3 separate blood pressure measurements \>180 mmHg (systolic) or \>100 mmHg (diastolic).
• Active illicit substance abuse or alcoholism (\>2 drinks/day regularly)
• Women who are currently breastfeeding.
• Pregnancy or wish to get pregnant in the next year.
• General contraindications to deep or conscious sedation, general anesthesia, high risk as determined by anesthesiologist (e.g., ASA score 4 or higher), or contraindications to upper GI endoscopy.

• Adults ≥18 years old but ≤ 65 years old. (Women of childbearing potential must be using one acceptable methods of contraception throughout the study.)
• Diagnosed with type 2 diabetes mellitus for ≥1 year but ≤ 8 years duration.
• Glycated haemoglobin ≤ 8.0% (64 mmol/mol).
• Fasting serum C-peptide ≥ 0.6 ng/mL.
• Body mass index ≥ 27.5 and ≤ 42.5 kg/m2.
• On a daily insulin (basal or combined with short-acting) for at least three months, with a dose ≤ 0.6 U/kg, with a stable dose (≤ 20%) over the last month.
• Able to comply with study requirements and understand and sign the informed consent form.