NCT06659146Recruiting
Thermotherapy in Addition to SOC Palliative Radiotherapy
Prospective Study to Assess the Real-world Implementation of Thermotherapy Using wIRA (Water-filtered Infrared A Superficial Hyperthermia) in Addition to Standard of Care (SOC) Palliative Radiotherapy (RT)
Source: ClinicalTrials.gov · Last updated 22 Dec 2025
Brief summary (registry, in English)
This study aims to investigate the efficacy and safety profile of superficial hyperthermia (wIRA) in addition to standard of care (SOC) palliative radiotherapy in patients with inoperable/incurable locally advanced or recurrent/metastatic HNSCC or cutaneous SCC superficial tumours not suitable for radical treatment. The investigators will assess the best objective response rate (ORR) of patients with Inoperable/incurable or recurrent/metastatic HNSCC or cSCC with superficial lesion(s) treated with the combination of superficial hyperthermia (wIRA) and palliative radiotherapy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 18 Jun 2024
- Start date
- 14 Oct 2024
- Primary completion date
- 1 Mar 2028
- Lead sponsor
- King's College London
- Diseases
- Head and neck cancer
- NCT number
- NCT06659146
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 14 Oct 2024 to the primary completion date, 1 Mar 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients are not suitable for one of the pre-specified palliative radiotherapy dose and fractionation
Other illness
- Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study.
Other
- No superficial tumour lesion or lymph node that is suitable for hydrosun® TWH1500 treatment.
Who the study is looking for
- Patient with histologically confirmed incurable or inoperable cancers with disease \[at least one superficial lesion(s) or lymph node(s)\] suitable for hydrosun® TWH1500 treatment
- Patient undergoing standard of care palliative radiotherapy (suitable with the pre-specified dose and fractionation in the protocol
- Aged ≥18 years old
- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1
- Patient with capacity to consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Guy's Cancer Centre Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Guy's and St Thomas' NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.