NCT06661018Completed
Effect Supplementation of COenzyme Q10 in Acute STEMI Underwent PPCI
The Effect of Coenzyme Q10 Supplementation on Global Longitudinal Strain Values in Acute ST Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention
Source: ClinicalTrials.gov · Last updated 28 Oct 2024
Brief summary (registry, in English)
Left ventricular remodeling can still occur after primary percutaneous coronary intervention (PCI). Global longitudinal strain (GLS) assessment has been used as a predictor of left ventricular remodeling. Coenzyme Q10 is known for its anti-inflammatory and antioxidant properties, which may help reduce cardiac remodeling. This study aims to determine the effect of CoQ10 administration after myocardial infarction as an adjunct to standard therapy on left ventricular remodeling, assessed through changes in GLS values. Researchers will compare Coenzyme Q10 to a placebo to see if Coenzyme Q10 has a greater effect on improving left ventricular GLS values in patients with ST-Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 46 (actual)
- First submitted
- 17 Oct 2024
- Start date
- 28 Jan 2024
- Primary completion date
- 30 Apr 2024
- Lead sponsor
- Universitas Diponegoro
- Diseases
- Coronary artery disease
- NCT number
- NCT06661018
What you commit to
- Study type: Interventional
- Participants enrolled: 46
- From 28 Jan 2024 to the primary completion date, 30 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who routinely consume CoQ10 prior to the study
- Patients with a history of previous acute myocardial infarction
- Patients with a history of previous PCI or fibrinolytic therapy
- Patients with a history of previous coronary artery bypass surgery
- Patients receiving warfarin therapy
Other illness
- Patients with hemodynamic conditions of Killip class III-IV and NYHA class III-IV
- Patients with heart valve disease greater than moderate severity
Other
- Patients with a diagnosis of isolated right ventricular infarction
- Patients with inadequate echocardiographic image quality (poor echo window)
Who the study is looking for
- Age \> 21 - 80 years
- Agree to participate in the study
- Patients with a diagnosis of Acute Myocardial Infarction with ST-Segment Elevation (AMI-STE) with onset \< 12 hours who underwent primary percutaneous coronary intervention (PCI)
- Successful primary PCI on the culprit lesion (residual stenosis \< 20%, TIMI flow III)
- Received standard medication therapy according to guidelines (Guideline-Directed Medical Therapy; GDMT) achieved during hospitalization
- Sinus rhythm at the time of echocardiographic examination
Age in the registry: 21 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dr. Kariadi Central General Hospital Coordinator of this site? Confirm its status | Semarang | Indonesia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.