NCT06662383Active, not recruitingPhase 3
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Retatrutide Compared to Tirzepatide in Adults Who Have Obesity
Source: ClinicalTrials.gov · Last updated 20 Jul 2026
Brief summary (registry, in English)
The main purpose of this study is to evaluate the efficacy and safety of retatrutide compared to tirzepatide in adults who have obesity. The study will last about 89 weeks.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 800 (estimated)
- First submitted
- 25 Oct 2024
- Start date
- 1 Nov 2024
- Primary completion date
- Nov 2026
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity
- NCT number
- NCT06662383
- EU CT number
- 2024-511450-49-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 800
- From 1 Nov 2024 to the primary completion date, Nov 2026
- 65 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening.
- Have a prior or planned surgical treatment for obesity.
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity.
- Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
- Have had within the past 90 days before screening:
- acute myocardial infarction
- cerebrovascular accident (stroke)
- coronary revascularization
- hospitalization for unstable angina, or
- hospitalization due to congestive heart failure.
Other illness
- Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2).
- Have New York Heart Association Functional Classification Class IV congestive heart failure.
- Have a history of chronic or acute pancreatitis.
Who the study is looking for
- Have obesity and a history of at least one self-reported unsuccessful dietary effort to reduce body weight.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (65)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro Médico Viamonte Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Consultorio de Investigación Clínica EMO SRL Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro de Investigaciones Metabólicas (CINME) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| DIM Clínica Privada Coordinator of this site? Confirm its status | Ramos Mejía | Argentina | Unknown status |
| Medizentrum Essen Borbeck Coordinator of this site? Confirm its status | Essen | Germany | Active, not recruiting |
| InnoDiab Forschung Gmbh Coordinator of this site? Confirm its status | Essen | Germany | Active, not recruiting |
| Diabetes Zentrum Wilhelmsburg GbR Coordinator of this site? Confirm its status | Hamburg | Germany | Active, not recruiting |
| Diabeteszentrum Hamburg West Coordinator of this site? Confirm its status | Hamburg | Germany | Active, not recruiting |
| Zentrum fur klinische Forschung - Köln Coordinator of this site? Confirm its status | Köln | Germany | Active, not recruiting |
| Ambenet GmbH Das Ambulante Behandlungsnetz Coordinator of this site? Confirm its status | Leipzig | Germany | Active, not recruiting |
| Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz Coordinator of this site? Confirm its status | Lingen | Germany | Active, not recruiting |
| RED Oncology GmbH Coordinator of this site? Confirm its status | Oldenburg In Holstein | Germany | Active, not recruiting |
| Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob Coordinator of this site? Confirm its status | Villingen-Schweningen | Germany | Active, not recruiting |
| NZOZ Specjalistyczny Osrodek Internistyczno - Diabetologiczny Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| Gabinet Leczenia Otylosci i Chorob Dietozaleznych Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| ZDROWIE OSTEO-MEDIC s.c. Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| Centrum Terapii Współczesnej Coordinator of this site? Confirm its status | Lodz | Poland | Active, not recruiting |
| EKAMED sp. z o.o. Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Terpa Sp. z o.o. Sp. k. Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Centrum Zdrowia Metabolicznego Coordinator of this site? Confirm its status | Poznan | Poland | Active, not recruiting |
| NZOZ Neuro-Kard Ilkowski i Partnerzy Spółka Partnerska Lekarzy Coordinator of this site? Confirm its status | Poznań | Poland | Active, not recruiting |
| NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki Coordinator of this site? Confirm its status | Ruda Śląska | Poland | Active, not recruiting |
| Ponce Medical School Foundation Inc. Coordinator of this site? Confirm its status | Ponce | Puerto Rico | Unknown status |
| Albany Medical College, Division of Community Endocrinology Coordinator of this site? Confirm its status | Albany | United States | Unknown status |
| Lynn Institute of Denver Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Pennington Biomedical Research Center Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| Great Lakes Research Group, Inc. Coordinator of this site? Confirm its status | Bay City | United States | Unknown status |
| Bridgeport Hospital Coordinator of this site? Confirm its status | Bridgeport | United States | Unknown status |
| Headlands Horizons LLC Coordinator of this site? Confirm its status | Brownsville | United States | Unknown status |
| Charlottesville Medical Research Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| WR-ClinSearch, LLC Coordinator of this site? Confirm its status | Chattanooga | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| StudyMetrix Research Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| ClinCept Clinical Research - MH Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Primed Clinical Research Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Lillestol Research Coordinator of this site? Confirm its status | Fargo | United States | Unknown status |
| Northeast Georgia Medical Center Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| PharmQuest Life Sciences LLC Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| Tribe Clinical Research LLC Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Las Vegas Endocrinology Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Encore Medical Research Coordinator of this site? Confirm its status | Hollywood | United States | Unknown status |
| East-West Medical Research Institute Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Houston Research Institute Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Next Level Urgent Care Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Suncoast Research Group Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| ONHEALTH Research Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Monroe Biomedical Research Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Yale University School Of Medicine Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Mary & Dick Allen Diabetes Center Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| New York Gastroenterology Associates Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Artemis Institute for Clinical Research Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Consano Clinical Research, LLC Coordinator of this site? Confirm its status | Shavano Park | United States | Unknown status |
| Great Lakes Research Institute Coordinator of this site? Confirm its status | Southfield | United States | Unknown status |
| Encompass Clinical Research Coordinator of this site? Confirm its status | Spring Valley | United States | Unknown status |
| Chrysalis Clinical Research Coordinator of this site? Confirm its status | St. George | United States | Unknown status |
| Pivotal Research Solutions Coordinator of this site? Confirm its status | Stonecrest | United States | Unknown status |
| Precision Clinical Research Coordinator of this site? Confirm its status | Sunrise | United States | Unknown status |
| Medical Advancement Centers of Arizona Coordinator of this site? Confirm its status | Tempe | United States | Unknown status |
| Westchester Medical Center Coordinator of this site? Confirm its status | Valhalla | United States | Unknown status |
| Einstein Clinical Research Coordinator of this site? Confirm its status | Vero Beach | United States | Unknown status |
| Diablo Clinical Research, Inc. Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Integrated Clinical Trial Services, Inc. Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Accellacare - Wilmington Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.