NCT06665984Recruiting
Greater Houston Area Pediatric Bipolar Registry
Source: ClinicalTrials.gov · Last updated 18 Feb 2026
Brief summary (registry, in English)
The purpose of this study is to perform a comprehensive research assessment of children and adolescents who meet The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for Bipolar Disorder (BD) , offspring of a parent with BD, and healthy controls (HC), to obtain blood samples and saliva samples from each subject to allow the evaluation for BD biomarkers and genetic information, to notify participants about future research studies they may qualify for , to recommend follow-up with an outpatient provider if needed and to use magnetic resonance imaging (MRI) (structural MRI and diffusion tensor imaging) to investigate brain structures and relevant pathways associated with mood and behavioral regulation, conversion from softer forms of the BD spectrum (BD-NOS) to harder forms (BD-I and BD-II) and possible early identification.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 4 Aug 2023
- Start date
- 6 Dec 2022
- Primary completion date
- 6 Dec 2027
- Lead sponsor
- The University of Texas Health Science Center, Houston
- Diseases
- Bipolar disorder
- NCT number
- NCT06665984
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 6 Dec 2022 to the primary completion date, 6 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Autism Spectrum Disorder (ASD)
- Developmental Intellectual Disorder
- Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
- For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability
- Any Psychiatric Diagnosis
- Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative
- Any family history of a neurological condition in a first-degree relative.
- Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
- Autism Spectrum Disorders (ASD)
- Intellectual Developmental Disorder
- Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
Other
- Schizophrenia
- Uncontrolled or severe medical problem per investigator judgment
- Mental Retardation/Intellectual Disability
- Schizophrenia
- Uncontrolled or severe medical problem per investigator judgement
- Schizophrenia
- Uncontrolled or severe medical problem per investigator judgement
Who the study is looking for
- Any current mood state (in the case of bipolar subjects)
- For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
- For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult
Age in the registry: 6 years to 17 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Texas Health Science Center at Houston Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.