NCT06666881Recruiting
Skeletal Muscle Mass Changes on Images for Prediction of Prognosis After Exercise Training in HNSCC Patients
(Health Promotion) Skeletal Muscle Mass Changes on Images for Prediction of Prognosis After Exercise Training in Head and Neck Cancer Patients
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
This project adopts a prospective study design. It is scheduled to enroll 60 participants diagnosed with Head and Neck cancer in this hospital, of which 30 are in the experimental group and 30 are in the control group. The purpose of this research is to analyze the skeletal muscle mass changes on images in Head and Neck cancer patients after exercise training and the association with systemic inflammatory markers. Investigators would like to know whether these images and biomarkers predict the prognosis of Head and Neck cancer. Subjects enrolled in the trial will receive 36 times of exercise training after concurrent chemoradiotherapy. Before and after the completion of exercise training, investigators will arrange (1) dual energy X-ray absorptiometry (DXA) to measure the whole-body skeletal muscle mass and appendicular skeletal muscle mass and (2) blood tests for markers of systemic inflammation. In addition to DXA, computed tomography (CT) is another image modality for skeletal muscle mass evaluation. Positron emission tomography - CT or whole-body CT for cancer staging are considered as baseline studies. The routine follow-up CT images are used to analyze the changes after exercise training. If magnetic resonance imaging is also performed during the follow-up period, images will also be collected and assessed as an alternative.If the experimental group can maintain or even improve skeletal muscle mass and can be reflected in blood tests and prognosis, the result may be able to apply on cancer treatment and disease followup.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 280 (estimated)
- First submitted
- 15 Oct 2024
- Start date
- 6 Jun 2023
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Chang Gung Memorial Hospital
- Diseases
- Head and neck cancer
- NCT number
- NCT06666881
What you commit to
- Study type: Interventional
- Planned participants: 280
- From 6 Jun 2023 to the primary completion date, 30 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Mental illness or any medical illness or concurrent illness that may be aggravated by exercise training or unmanageable
Other illness
- Any medical condition that unsuitable for exercise training
Other
- ECOG PS≥2
- Participants with intolerance basic exercise training, or without CCRT treatment
- refure to do the trial procedures: exercise training, blood drawing and all the procedures in the trial.
- can't get the data for the whole-body computed tomography
Who the study is looking for
- Age ≥20
- Pathology:Squamous cell carcinoma
- Need CCRT treatment
- ECOG PS\<2
- Agree with blood drawing, exercise training, and all the procedures in the trial.
Age in the registry: 20 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| New Taipei City TuCheng Hospital Coordinator of this site? Confirm its status | New Taipei City | Taiwan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.